Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid

Raymond C. F.  Jolles; Alan K. Crockett; David C. Rees; Ian Gilbert

doi:10.1016/0957-4166(94)80075-8

Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid

Raymond C. F. Jolles, Alan K. Crockett, David C. Rees, Ian Gilbert

Research output: Contribution to journal › Comment/debate › peer-review

21 Citations (Scopus)

Abstract

The synthesis at a homochiral a,a-disubstituted a,ß-amino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-acids.

Original language	English
Pages (from-to)	1661-1664
Number of pages	4
Journal	Tetrahedron: Asymmetry
Volume	5
Issue number	9
DOIs	https://doi.org/10.1016/0957-4166(94)80075-8
Publication status	Published - 1994

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@article{078080f845994de08ceb6138d34d50bb,

title = "Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid",

abstract = "The synthesis at a homochiral a,a-disubstituted a,{\ss}-amino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-acids. ",

author = "Jolles, {Raymond C. F.} and Crockett, {Alan K.} and Rees, {David C.} and Ian Gilbert",

year = "1994",

doi = "10.1016/0957-4166(94)80075-8",

language = "English",

volume = "5",

pages = "1661--1664",

journal = "Tetrahedron: Asymmetry",

issn = "0957-4166",

publisher = "Elsevier",

number = "9",

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TY - JOUR

T1 - Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid

AU - Jolles, Raymond C. F.

AU - Crockett, Alan K.

AU - Rees, David C.

AU - Gilbert, Ian

PY - 1994

Y1 - 1994

N2 - The synthesis at a homochiral a,a-disubstituted a,ß-amino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-acids.

AB - The synthesis at a homochiral a,a-disubstituted a,ß-amino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-acids.

U2 - 10.1016/0957-4166(94)80075-8

DO - 10.1016/0957-4166(94)80075-8

M3 - Comment/debate

SN - 0957-4166

VL - 5

SP - 1661

EP - 1664

JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

IS - 9

ER -

Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid

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