Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid

TY - JOUR

T1 - Synthesis of a homochiral α,α-disubstituted α,β-diamino-acid

AU - Jolles, Raymond C. F.

AU - Crockett, Alan K.

AU - Rees, David C.

AU - Gilbert, Ian

PY - 1994

Y1 - 1994

N2 - The synthesis at a homochiral a,a-disubstituted a,ß-amino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-acids.

AB - The synthesis at a homochiral a,a-disubstituted a,ß-amino-acid is described from norleucine using stereospecific alkylation of a homochiral oxazolidinone enolate; an optically active pseudotetrapeptide analogue of CCK-4 is prepared to show an application of such diamino-acids.

U2 - 10.1016/0957-4166(94)80075-8

DO - 10.1016/0957-4166(94)80075-8

M3 - Comment/debate

SN - 0957-4166

VL - 5

SP - 1661

EP - 1664

JO - Tetrahedron: Asymmetry

JF - Tetrahedron: Asymmetry

IS - 9

ER -