Synthesis of a Series of Diaminoindoles

James S. Martin, Claire J. Mackenzie, Ian H. Gilbert (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

Abstract

A selection of 3,4-diaminoindoles were required for a recent drug discovery project. To this end, a 10-step synthesis was developed from 4-nitroindole. This synthesis was subsequently adapted and used to synthesize 3,5-; 3,6-; and 3,7-diaminoindoles from the corresponding 5-, 6-, or 7-nitroindole. These novel intermediates feature orthogonal protecting groups that allow them to be further diversified. This is the first reported synthesis of these types of compounds.

Original languageEnglish
Pages (from-to)11333-11340
Number of pages8
JournalJournal of Organic Chemistry
Volume86
Issue number17
Early online date5 Aug 2021
DOIs
Publication statusPublished - 3 Sep 2021

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