Synthesis of enantiopure α'-amino α,β-epoxy ketones from α'-amino bromomethyl ketones

José Barluenga, Beatriz Baragana, José M. Concellón, Alejandro Piñera-Nicolás, M. Rosario Díaz, Santiago García-Granda

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.

Original languageEnglish
Pages (from-to)5048-5052
Number of pages5
JournalJournal of Organic Chemistry
Volume64
Issue number14
DOIs
Publication statusPublished - 9 Jul 1999

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