Synthesis of enantiopure α'-amino α,β-epoxy ketones from α'-amino bromomethyl ketones

José Barluenga; Beatriz Baragana; José M. Concellón; Alejandro Piñera-Nicolás; M. Rosario Díaz; Santiago García-Granda

doi:10.1021/jo982435z

Synthesis of enantiopure α'-amino α,β-epoxy ketones from α'-amino bromomethyl ketones

José Barluenga, Beatriz Baragana, José M. Concellón, Alejandro Piñera-Nicolás, M. Rosario Díaz, Santiago García-Granda

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.

Original language	English
Pages (from-to)	5048-5052
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	64
Issue number	14
DOIs	https://doi.org/10.1021/jo982435z
Publication status	Published - 9 Jul 1999

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo982435z

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abstract = "Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.",

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T1 - Synthesis of enantiopure α'-amino α,β-epoxy ketones from α'-amino bromomethyl ketones

AU - Barluenga, José

AU - Baragana, Beatriz

AU - Concellón, José M.

AU - Piñera-Nicolás, Alejandro

AU - Rosario Díaz, M.

AU - García-Granda, Santiago

PY - 1999/7/9

Y1 - 1999/7/9

N2 - Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.

AB - Preparation of enantiomerically pure α'-amino α,β-epoxy ketones 2 in an efficient synthesis starting from α'-amino bromomethyl ketones 5 and the obtention of amino diepoxido 10a as synthetic application of 2 are described. We also report the generalization of the synthesis of 1-aminoalkyl halomethyl ketones to their bromo derivatives.

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DO - 10.1021/jo982435z

M3 - Article

AN - SCOPUS:0033056130

SN - 0022-3263

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SP - 5048

EP - 5052

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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ER -

Synthesis of enantiopure α'-amino α,β-epoxy ketones from α'-amino bromomethyl ketones

Abstract

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