Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

Vladimir S. Borodkin; Michael A. J. Ferguson; Andrei V. Nikolaev

doi:10.1016/j.tetlet.2003.11.022

Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

Vladimir S. Borodkin, Michael A. J. Ferguson, Andrei V. Nikolaev

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating a-d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.

Original language	English
Pages (from-to)	857-862
Number of pages	6
Journal	Tetrahedron Letters
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2003.11.022
Publication status	Published - 2004

Keywords

Bisubstrate inhibitors
Phosphate transfer
Phosphonic acids

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10.1016/j.tetlet.2003.11.022

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title = "Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase",

abstract = "Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating a-d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.",

keywords = "Bisubstrate inhibitors, Phosphate transfer, Phosphonic acids",

author = "Borodkin, {Vladimir S.} and Ferguson, {Michael A. J.} and Nikolaev, {Andrei V.}",

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journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

AU - Borodkin, Vladimir S.

AU - Ferguson, Michael A. J.

AU - Nikolaev, Andrei V.

N1 - dc.publisher: Elsevier

PY - 2004

Y1 - 2004

N2 - Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating a-d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.

AB - Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating a-d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.

KW - Bisubstrate inhibitors

KW - Phosphate transfer

KW - Phosphonic acids

U2 - 10.1016/j.tetlet.2003.11.022

DO - 10.1016/j.tetlet.2003.11.022

M3 - Article

SN - 0040-4039

VL - 45

SP - 857

EP - 862

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

Abstract

Keywords

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