Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase

Vladimir S. Borodkin, Michael A. J. Ferguson, Andrei V. Nikolaev

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating a-d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.
    Original languageEnglish
    Pages (from-to)857-862
    Number of pages6
    JournalTetrahedron Letters
    Volume45
    Issue number4
    DOIs
    Publication statusPublished - 2004

    Keywords

    • Bisubstrate inhibitors
    • Phosphate transfer
    • Phosphonic acids

    Fingerprint Dive into the research topics of 'Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-d-mannosyl phosphate transferase'. Together they form a unique fingerprint.

    Cite this