Abstract
Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating a-d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.
Original language | English |
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Pages (from-to) | 857-862 |
Number of pages | 6 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2004 |
Keywords
- Bisubstrate inhibitors
- Phosphate transfer
- Phosphonic acids