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A small zinc-binding group (ZBG) library of deoxy-2-C-branched-monosaccharides, for example, 1,5-anhydroglucitols, consisting of either monodentate ligand binding carboxylic acids or bidentate ligand binding hydroxamic acids, were prepared to assess the zinc affinity of the putative metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1 -> 6)-phosphatidylinositol de-N-acetylase (EC 22.214.171.124) of glycosylphosphatidylinositol biosynthesis. The N-ureido thioglucoside was also synthesised and added to the ZBG library because a previous N-ureido analogue, synthesised by us, had inhibitory activity against the aforementioned de-N-acetylase, presumably via the N-ureido motif. (C) 2011 Elsevier Ltd. All rights reserved.
- Glycosylphosphatidylinositol (GPI) biosynthesis
- Zinc metalloenzyme inhibitor
- Zinc-binding group
- Branched monosaccharides, Phosphatidylinositol de-N-acetylase
- AFRICAN SLEEPING SICKNESS
- GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS
- INOSITOL ACYLATION
- ANCHORED PROTEINS
- MEMBRANE ANCHOR
FingerprintDive into the research topics of 'Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei'. Together they form a unique fingerprint.
- 1 Finished
Aref#d: 20731. The Biosynthesis of Glycoproteins in Trypanosoma Brucei: Basic and Translational Research
1/10/08 → 31/05/14