Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown, Brian W. Fox, John A. Hadfield, Alan T. McGown, Stephen P. Mayalarp, George R. Pettit, Julie A. Woods

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    30 Citations (Scopus)

    Abstract

    Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

    Original languageEnglish
    Pages (from-to)577-581
    Number of pages5
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number5
    DOIs
    Publication statusPublished - 1995

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