Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown, Brian W. Fox, John A. Hadfield, Alan T. McGown, Stephen P. Mayalarp, George R. Pettit, Julie A. Woods

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    30 Citations (Scopus)

    Abstract

    Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

    Original languageEnglish
    Pages (from-to)577-581
    Number of pages5
    JournalJournal of the Chemical Society - Perkin Transactions 1
    Issue number5
    DOIs
    Publication statusPublished - 1995

    Cite this

    Brown, R. T., Fox, B. W., Hadfield, J. A., McGown, A. T., Mayalarp, S. P., Pettit, G. R., & Woods, J. A. (1995). Synthesis of water-soluble sugar derivatives of combretastatin A-4. Journal of the Chemical Society - Perkin Transactions 1, (5), 577-581. https://doi.org/10.1039/P19950000577