Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown; Brian W. Fox; John A. Hadfield; Alan T. McGown; Stephen P. Mayalarp; George R. Pettit; Julie A. Woods

doi:10.1039/P19950000577

Synthesis of water-soluble sugar derivatives of combretastatin A-4

Richard T. Brown, Brian W. Fox, John A. Hadfield, Alan T. McGown, Stephen P. Mayalarp, George R. Pettit, Julie A. Woods

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Journal of the Chemical Society - Perkin Transactions 1
Issue number	5
DOIs	https://doi.org/10.1039/P19950000577
Publication status	Published - 1995

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@article{c710f406485a4302a5ecd5a6d338a2bd,

title = "Synthesis of water-soluble sugar derivatives of combretastatin A-4",

abstract = "Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.",

author = "Brown, {Richard T.} and Fox, {Brian W.} and Hadfield, {John A.} and McGown, {Alan T.} and Mayalarp, {Stephen P.} and Pettit, {George R.} and Woods, {Julie A.}",

year = "1995",

doi = "10.1039/P19950000577",

language = "English",

pages = "577--581",

journal = "Journal of the Chemical Society - Perkin Transactions 1",

issn = "0300-922X",

publisher = "Royal Society of Chemistry",

number = "5",

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TY - JOUR

T1 - Synthesis of water-soluble sugar derivatives of combretastatin A-4

AU - Brown, Richard T.

AU - Fox, Brian W.

AU - Hadfield, John A.

AU - McGown, Alan T.

AU - Mayalarp, Stephen P.

AU - Pettit, George R.

AU - Woods, Julie A.

PY - 1995

Y1 - 1995

N2 - Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

AB - Three sugar derivatives (6, 7 and 13) of the antimitotic agent combretastatin A-4 1 have been synthesized. Two of these water-soluble derivatives (6, 13) showed strong cytotoxicity to the murine P388 cell line.

U2 - 10.1039/P19950000577

DO - 10.1039/P19950000577

M3 - Article

SN - 0300-922X

SP - 577

EP - 581

JO - Journal of the Chemical Society - Perkin Transactions 1

JF - Journal of the Chemical Society - Perkin Transactions 1

IS - 5

ER -

Synthesis of water-soluble sugar derivatives of combretastatin A-4

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