Abstract
The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.
Original language | English |
---|---|
Pages (from-to) | 142-149 |
Number of pages | 8 |
Journal | Organic and Biomolecular Chemistry |
Volume | 2 |
Issue number | 1 |
DOIs | |
Publication status | Published - 7 Jan 2004 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry(all)