Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Edward M. Rosser, Simon Morton, Kate S. Ashton, Philip Cohen (Lead / Corresponding author), Alison N. Hulme (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

    Original languageEnglish
    Pages (from-to)142-149
    Number of pages8
    JournalOrganic and Biomolecular Chemistry
    Volume2
    Issue number1
    DOIs
    Publication statusPublished - 7 Jan 2004

    Fingerprint Dive into the research topics of 'Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways'. Together they form a unique fingerprint.

  • Cite this