Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Edward M. Rosser; Simon Morton; Kate S. Ashton; Philip Cohen; Alison N. Hulme

doi:10.1039/b311242j

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Edward M. Rosser, Simon Morton, Kate S. Ashton, Philip Cohen (Lead / Corresponding author), Alison N. Hulme (Lead / Corresponding author)

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28 Citations (Scopus)

Abstract

The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

Original language	English
Pages (from-to)	142-149
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	2
Issue number	1
DOIs	https://doi.org/10.1039/b311242j
Publication status	Published - 7 Jan 2004

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Chemistry

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abstract = "The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.",

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AU - Hulme, Alison N.

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AB - The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

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Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Abstract

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