Synthetic applications of 1-aminoalkyl chloromethyl ketones. Synthesis of enantiopure 3-azetidinols and aminoalkyl epoxides

José Barluenga, Beatriz Baragaña, José M. Concellón

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Addition of several organocerium compounds to chiral 1-aminoalkyl chloromethyl ketones 1 affords, after deprotection, enantiomerically pure 3- azetidinols 5. The synthesis of enantiopure amino epoxides 8 is also described by successive treatment of chiral α-amino ketones 1 with organocerium compounds and methyllithium.

Original languageEnglish
Pages (from-to)5974-5977
Number of pages4
JournalJournal of Organic Chemistry
Volume62
Issue number17
DOIs
Publication statusPublished - 22 Aug 1997

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