Synthetic fragments of antigenic lipophosphoglycans from Leishmania major and Leishmania mexicana and their use for characterisation of the Leishmania elongating alpha-D-mannopyranosylphosphate transferase

Adrian P. Higson, Andrew J. Ross, Yury E. Tsvetkov, Françoise H. Routier, Olga V. Sizova, Michael A. J. Ferguson, Andrei V. Nikolaev

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    22 Citations (Scopus)

    Abstract

    The phosphorylated branched heptasaccharides 7 and 8, the octasaccharide 9 and the phosphorylated trisaccharides 5 and 6, which are fragments of the phosphoglycan portion of the lipophosphoglycans from Leishmania mexicana (5) or L. major (6–9), were synthesised by using the hydrogenphosphonate method for the preparation of phosphodiester bridges. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania elongating -D-mannosylphosphate transferase.
    Original languageEnglish
    Pages (from-to)2019-2030
    Number of pages12
    JournalChemistry: a European Journal
    Volume11
    Issue number7
    DOIs
    Publication statusPublished - 2005

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