Synthetic Routes Towards the Synthesis of Geminal α-Difunctionalized Ketones

David P. Day, Jorge A. M. Vargas, Antonio C. B. Burtoloso (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The importance of gem-difunctionalized ketones is represented by their broad applications across chemical boundaries over recent years. The interesting reactivities that this class of compounds possess have made them ideal building blocks to access high-value organic molecules. Furthermore, the gem-difunctionalized ketone moiety has featured in numerous bioactive molecules. For these reasons, a plethora of routes to access such significant molecules have been developed by research groups worldwide – this account looks at delineating the synthesis of gem-difunctionalized ketones from carbonyl substrates, diazo compounds, sulfur ylides and alkynyl reactants.

Original languageEnglish
Pages (from-to)2837-2854
Number of pages18
JournalChemical Record
Volume21
Issue number10
Early online date3 Feb 2021
DOIs
Publication statusPublished - Oct 2021

Keywords

  • alkoxylation
  • gem-difunctionalized ketones
  • halogenation
  • organic chemistry
  • organic synthesis

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