Projects per year
Abstract
Neuropathic pain (NP) is an increasingly common chronic pain state and a major health burden, affecting approximately 7-10% of the general population. Emerging evidence suggests that genetic factors could partially explain individual susceptibility to NP and the estimated heritability in twins is 37%. The aim of this study was to systematically review and summarize the studies in humans that have investigated the influence of genetic factors associated with NP. We conducted a comprehensive literature search and performed meta-analyses of all the potential genetic variants associated with NP. We reviewed 29 full-text articles and identified 28 genes that were significantly associated with NP, mainly involved in neurotransmission, immune response, and metabolism. Genetic variants in HLA genes, COMT, OPRM1, TNFA, IL6, and GCH1, were found to have an association with NP in more than one study. In the meta-analysis, polymorphisms in HLA-DRB1*13 (OR,2.96; CI,1.93-4.56), HLADRB1*04 (OR,1.40; CI, 1.02-1.93), HLA-DQB1*03 (OR,2.86; CI,1.57-5.21), HLA-A*33 (OR,2.32; CI,1.42-3.80), and HLA-B*44 (OR,3.17; CI,2.22-4.55) were associated with significantly increased risk of developing NP whereas HLA-A*02 (OR,0.64; CI,0.47- 0.87) conferred reduced risk and neither rs1799971 in OPRM1 (OR, 0.55; CI, 0.27- 1.11) nor rs4680 in COMT (OR, 0.95; CI, 0.81-1.13) were significantly associated with NP. These findings demonstrate an important and specific contribution of genetic factors to the risk of developing NP. However, large-scale replication studies are required to validate these candidate genes. Our review also highlights the need for genome-wide association studies with consistent case definition to elucidate the genetic architecture underpinning NP.
Original language | English |
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Pages (from-to) | 825-848 |
Number of pages | 24 |
Journal | Pain |
Volume | 159 |
Issue number | 5 |
Early online date | 18 Jan 2018 |
DOIs | |
Publication status | Published - May 2018 |
Keywords
- Neuropathic pain
- Genetic risk factor
- Polymorphisms
- Genome-wide association studies
- Candidate gene association studies
- Systematic review
- Meta-analysis
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Dive into the research topics of 'Systematic review and meta-analysis of genetic risk factors for neuropathic pain'. Together they form a unique fingerprint.Projects
- 1 Finished
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DOLORisk: Understanding Risk Factors and Determinants for Neuropathic Pain (Joint with Oxford University and others)
Meng, W. (Investigator), Palmer, C. (Investigator) & Smith, B. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/07/15 → 30/09/20
Project: Research
Student theses
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Genetic factors associated with neuropathic pain
Veluchamy, A. (Author), Smith, B. (Supervisor) & Palmer, C. (Supervisor), 2019Student thesis: Doctoral Thesis › Doctor of Philosophy
Profiles
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Smith, Blair, FRSE MD MEd FRCGP FHEA FFPMRCA FRCP Edin
- Population Health and Genomics - Clinical Professor (Teaching and Research) of Population Health Science
Person: Academic