Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

Esther Castanys-Muñoz, Kathy Kennedy, Eurídice Castañeda-Gutiérrez, Stewart Forsyth, Keith M. Godfrey, Berthold Koletzko, Susan E. Ozanne, Ricardo Rueda, Marieke Schoemaker, Eline M. van der Beek, Stef van Buuren, Ken K. Ong (Lead / Corresponding author)

Research output: Contribution to journalReview article

50 Citations (Scopus)
142 Downloads (Pure)

Abstract

We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affects neurodevelopment and metabolic outcomes in term-born small for gestational age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure, but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and blood pressure.

CONCLUSION: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)1230-1238
Number of pages9
JournalActa Paediatrica
Volume106
Issue number8
Early online date6 Apr 2017
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Journal article
  • Review
  • Adiposity
  • Insulin resistance
  • Neurodevelopment
  • Postnatal growth
  • Small for gestational age

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    Castanys-Muñoz, E., Kennedy, K., Castañeda-Gutiérrez, E., Forsyth, S., Godfrey, K. M., Koletzko, B., Ozanne, S. E., Rueda, R., Schoemaker, M., van der Beek, E. M., van Buuren, S., & Ong, K. K. (2017). Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. Acta Paediatrica, 106(8), 1230-1238. https://doi.org/10.1111/apa.13868