Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

Esther Castanys-Muñoz; Kathy Kennedy; Eurídice Castañeda-Gutiérrez; Stewart Forsyth; Keith M. Godfrey; Berthold Koletzko; Susan E. Ozanne; Ricardo Rueda; Marieke  Schoemaker; Eline M. van der Beek; Stef van Buuren; Ken K. Ong

doi:10.1111/apa.13868

Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

Esther Castanys-Muñoz, Kathy Kennedy, Eurídice Castañeda-Gutiérrez, Stewart Forsyth, Keith M. Godfrey, Berthold Koletzko, Susan E. Ozanne, Ricardo Rueda, Marieke Schoemaker, Eline M. van der Beek, Stef van Buuren, Ken K. Ong (Lead / Corresponding author)

Undergraduate Medicine

Research output: Contribution to journal › Review article › peer-review

93 Citations (Scopus)

236 Downloads (Pure)

Abstract

We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affects neurodevelopment and metabolic outcomes in term-born small for gestational age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure, but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and blood pressure.

CONCLUSION: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants. This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	1230-1238
Number of pages	9
Journal	Acta Paediatrica
Volume	106
Issue number	8
Early online date	6 Apr 2017
DOIs	https://doi.org/10.1111/apa.13868
Publication status	Published - Aug 2017

Keywords

Journal article
Review
Adiposity
Insulin resistance
Neurodevelopment
Postnatal growth
Small for gestational age

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10.1111/apa.13868Licence: CC BY

Final Published Version
©2017 The Authors. Acta Pædiatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Pædiatrica 2017106, pp.1230–1238This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited
Final published version, 163 KBLicence: CC BY

Cite this

Castanys-Muñoz, E., Kennedy, K., Castañeda-Gutiérrez, E., Forsyth, S., Godfrey, K. M., Koletzko, B., Ozanne, S. E., Rueda, R., Schoemaker, M., van der Beek, E. M., van Buuren, S., & Ong, K. K. (2017). Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. Acta Paediatrica, 106(8), 1230-1238. https://doi.org/10.1111/apa.13868

@article{f8d3fe5e81e74480a5b9ed90af34032c,

title = "Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes",

abstract = "We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affects neurodevelopment and metabolic outcomes in term-born small for gestational age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure, but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and blood pressure.CONCLUSION: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants. This article is protected by copyright. All rights reserved.",

keywords = "Journal article, Review, Adiposity, Insulin resistance, Neurodevelopment , Postnatal growth , Small for gestational age",

author = "Esther Castanys-Mu{\~n}oz and Kathy Kennedy and Eur{\'i}dice Casta{\~n}eda-Guti{\'e}rrez and Stewart Forsyth and Godfrey, {Keith M.} and Berthold Koletzko and Ozanne, {Susan E.} and Ricardo Rueda and Marieke Schoemaker and {van der Beek}, {Eline M.} and {van Buuren}, Stef and Ong, {Ken K.}",

note = "The expert group received funding from the ILSI Europe Early Nutrition and Long-Term Health (formerly Metabolic Imprinting) Task Force. Industry members of this task force are listed on the ILSI Europe website at http://ilsi.eu/task-forces/nutrition/early-nutrition-and-long-term-health/. Experts are not paid for the time spent on this work; however, the non-industry members within the expert group received a small compensatory sum (honoraria) and travel support from the Early Nutrition and Long-Term Health Task Force to attend meetings to discuss the review",

year = "2017",

month = aug,

doi = "10.1111/apa.13868",

language = "English",

volume = "106",

pages = "1230--1238",

journal = "Acta Paediatrica",

issn = "0803-5253",

publisher = "Wiley",

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Castanys-Muñoz, E, Kennedy, K, Castañeda-Gutiérrez, E, Forsyth, S, Godfrey, KM, Koletzko, B, Ozanne, SE, Rueda, R, Schoemaker, M, van der Beek, EM, van Buuren, S & Ong, KK 2017, 'Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes', Acta Paediatrica, vol. 106, no. 8, pp. 1230-1238. https://doi.org/10.1111/apa.13868

Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. / Castanys-Muñoz, Esther; Kennedy, Kathy; Castañeda-Gutiérrez, Eurídice et al.
In: Acta Paediatrica, Vol. 106, No. 8, 08.2017, p. 1230-1238.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

AU - Castanys-Muñoz, Esther

AU - Kennedy, Kathy

AU - Castañeda-Gutiérrez, Eurídice

AU - Forsyth, Stewart

AU - Godfrey, Keith M.

AU - Koletzko, Berthold

AU - Ozanne, Susan E.

AU - Rueda, Ricardo

AU - Schoemaker, Marieke

AU - van der Beek, Eline M.

AU - van Buuren, Stef

AU - Ong, Ken K.

N1 - The expert group received funding from the ILSI Europe Early Nutrition and Long-Term Health (formerly Metabolic Imprinting) Task Force. Industry members of this task force are listed on the ILSI Europe website at http://ilsi.eu/task-forces/nutrition/early-nutrition-and-long-term-health/. Experts are not paid for the time spent on this work; however, the non-industry members within the expert group received a small compensatory sum (honoraria) and travel support from the Early Nutrition and Long-Term Health Task Force to attend meetings to discuss the review

PY - 2017/8

Y1 - 2017/8

N2 - We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affects neurodevelopment and metabolic outcomes in term-born small for gestational age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure, but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and blood pressure.CONCLUSION: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants. This article is protected by copyright. All rights reserved.

AB - We systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affects neurodevelopment and metabolic outcomes in term-born small for gestational age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure, but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and blood pressure.CONCLUSION: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term-born SGA infants. This article is protected by copyright. All rights reserved.

KW - Journal article

KW - Review

KW - Adiposity

KW - Insulin resistance

KW - Neurodevelopment

KW - Postnatal growth

KW - Small for gestational age

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DO - 10.1111/apa.13868

M3 - Review article

C2 - 28382722

SN - 0803-5253

VL - 106

SP - 1230

EP - 1238

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 8

ER -

Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes

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Keywords

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