Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis

a TASCFORCE study

Jonathan R. Weir-McCall, Matthew Lambert, Stephen J. Gandy, Jill J. F. Belch, Ian Cavin, Shelley A. Henderson, Roberta Littleford, Jennifer A. Macfarlane, Shona Z. Matthew, R. Stephen Nicholas, Allan D. Struthers, Frank Sullivan, Richard D. White, J. Graeme Houston (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.

Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).

Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).

Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

Original languageEnglish
Article number7
Pages (from-to)1-11
Number of pages11
JournalJournal of Cardiovascular Magnetic Resonance
Volume20
Issue number1
DOIs
Publication statusPublished - 30 Jan 2018

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Ventricular Remodeling
Arteriosclerosis
Atherosclerosis
Compliance
Atherosclerotic Plaques
Magnetic Resonance Spectroscopy
Stroke Volume
Angiography
Pathologic Constriction
Cardiovascular Diseases
Blood Pressure
Population

Keywords

  • Arterial complaince
  • Arteriosclerosis
  • Atherosclerosis
  • Cardiovascular risk
  • Left ventricle

Cite this

Weir-McCall, Jonathan R. ; Lambert, Matthew ; Gandy, Stephen J. ; Belch, Jill J. F. ; Cavin, Ian ; Henderson, Shelley A. ; Littleford, Roberta ; Macfarlane, Jennifer A. ; Matthew, Shona Z. ; Nicholas, R. Stephen ; Struthers, Allan D. ; Sullivan, Frank ; White, Richard D. ; Houston, J. Graeme . / Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis : a TASCFORCE study. In: Journal of Cardiovascular Magnetic Resonance . 2018 ; Vol. 20, No. 1. pp. 1-11.
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title = "Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study",
abstract = "Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20{\%} 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).Results: One thousand five hundred fifteen (38{\%} male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95{\%}CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95{\%}CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95{\%}CI -0.15--0.086),p < 0.001 in females).Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.",
keywords = "Arterial complaince, Arteriosclerosis, Atherosclerosis, Cardiovascular risk, Left ventricle",
author = "Weir-McCall, {Jonathan R.} and Matthew Lambert and Gandy, {Stephen J.} and Belch, {Jill J. F.} and Ian Cavin and Henderson, {Shelley A.} and Roberta Littleford and Macfarlane, {Jennifer A.} and Matthew, {Shona Z.} and Nicholas, {R. Stephen} and Struthers, {Allan D.} and Frank Sullivan and White, {Richard D.} and Houston, {J. Graeme}",
note = "The present study was funded by the Souter Charitable Foundation and the Chest, Heart and Stroke Scotland Charity. The statistician was funded by TENOVUS, Tayside. JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship. Neither group had any role in: study design, the collection, analysis, and interpretation of data; in the writing of the manuscript; nor in the decision to submit the manuscript for publication.",
year = "2018",
month = "1",
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language = "English",
volume = "20",
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journal = "Journal of Cardiovascular Magnetic Resonance",
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Weir-McCall, JR, Lambert, M, Gandy, SJ, Belch, JJF, Cavin, I, Henderson, SA, Littleford, R, Macfarlane, JA, Matthew, SZ, Nicholas, RS, Struthers, AD, Sullivan, F, White, RD & Houston, JG 2018, 'Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study', Journal of Cardiovascular Magnetic Resonance , vol. 20, no. 1, 7, pp. 1-11. https://doi.org/10.1186/s12968-018-0428-0

Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis : a TASCFORCE study. / Weir-McCall, Jonathan R.; Lambert, Matthew; Gandy, Stephen J.; Belch, Jill J. F.; Cavin, Ian; Henderson, Shelley A.; Littleford, Roberta; Macfarlane, Jennifer A.; Matthew, Shona Z.; Nicholas, R. Stephen ; Struthers, Allan D.; Sullivan, Frank; White, Richard D.; Houston, J. Graeme (Lead / Corresponding author).

In: Journal of Cardiovascular Magnetic Resonance , Vol. 20, No. 1, 7, 30.01.2018, p. 1-11.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis

T2 - a TASCFORCE study

AU - Weir-McCall, Jonathan R.

AU - Lambert, Matthew

AU - Gandy, Stephen J.

AU - Belch, Jill J. F.

AU - Cavin, Ian

AU - Henderson, Shelley A.

AU - Littleford, Roberta

AU - Macfarlane, Jennifer A.

AU - Matthew, Shona Z.

AU - Nicholas, R. Stephen

AU - Struthers, Allan D.

AU - Sullivan, Frank

AU - White, Richard D.

AU - Houston, J. Graeme

N1 - The present study was funded by the Souter Charitable Foundation and the Chest, Heart and Stroke Scotland Charity. The statistician was funded by TENOVUS, Tayside. JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship. Neither group had any role in: study design, the collection, analysis, and interpretation of data; in the writing of the manuscript; nor in the decision to submit the manuscript for publication.

PY - 2018/1/30

Y1 - 2018/1/30

N2 - Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

AB - Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

KW - Arterial complaince

KW - Arteriosclerosis

KW - Atherosclerosis

KW - Cardiovascular risk

KW - Left ventricle

U2 - 10.1186/s12968-018-0428-0

DO - 10.1186/s12968-018-0428-0

M3 - Article

VL - 20

SP - 1

EP - 11

JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

SN - 1097-6647

IS - 1

M1 - 7

ER -