Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study

Jonathan R. Weir-McCall; Matthew Lambert; Stephen J. Gandy; Jill J. F. Belch; Ian Cavin; Shelley A. Henderson; Roberta Littleford; Jennifer A. Macfarlane; Shona Z. Matthew; R. Stephen  Nicholas; Allan D. Struthers; Frank Sullivan; Richard D. White; J. Graeme  Houston

doi:10.1186/s12968-018-0428-0

Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study

Jonathan R. Weir-McCall, Matthew Lambert, Stephen J. Gandy, Jill J. F. Belch, Ian Cavin, Shelley A. Henderson, Roberta Littleford, Jennifer A. Macfarlane, Shona Z. Matthew, R. Stephen Nicholas, Allan D. Struthers, Frank Sullivan, Richard D. White, J. Graeme Houston (Lead / Corresponding author)

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Abstract

Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.

Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).

Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).

Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

Original language	English
Article number	7
Pages (from-to)	1-11
Number of pages	11
Journal	Journal of Cardiovascular Magnetic Resonance (JCMR)
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12968-018-0428-0
Publication status	Published - 30 Jan 2018

Keywords

Arterial complaince
Arteriosclerosis
Atherosclerosis
Cardiovascular risk
Left ventricle

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12968-018-0428-0Licence: CC BY

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© The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 1.53 MBLicence: CC BY

Belch, Jill
- Cardiovascular Research - Clinical Professor (Teaching and Research) of Vascular Medicine
Person: Academic

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Weir-McCall, J. R., Lambert, M., Gandy, S. J., Belch, J. J. F., Cavin, I., Henderson, S. A., Littleford, R., Macfarlane, J. A., Matthew, S. Z., Nicholas, R. S., Struthers, A. D., Sullivan, F., White, R. D., & Houston, J. G. (2018). Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. Journal of Cardiovascular Magnetic Resonance (JCMR), 20(1), 1-11. Article 7. https://doi.org/10.1186/s12968-018-0428-0

@article{26f8daf104a941ecb5024e3d73c2d004,

title = "Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study",

abstract = "Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.",

keywords = "Arterial complaince, Arteriosclerosis, Atherosclerosis, Cardiovascular risk, Left ventricle",

author = "Weir-McCall, {Jonathan R.} and Matthew Lambert and Gandy, {Stephen J.} and Belch, {Jill J. F.} and Ian Cavin and Henderson, {Shelley A.} and Roberta Littleford and Macfarlane, {Jennifer A.} and Matthew, {Shona Z.} and Nicholas, {R. Stephen} and Struthers, {Allan D.} and Frank Sullivan and White, {Richard D.} and Houston, {J. Graeme}",

note = "The present study was funded by the Souter Charitable Foundation and the Chest, Heart and Stroke Scotland Charity. The statistician was funded by TENOVUS, Tayside. JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship. Neither group had any role in: study design, the collection, analysis, and interpretation of data; in the writing of the manuscript; nor in the decision to submit the manuscript for publication.",

year = "2018",

month = jan,

day = "30",

doi = "10.1186/s12968-018-0428-0",

language = "English",

volume = "20",

pages = "1--11",

journal = "Journal of Cardiovascular Magnetic Resonance (JCMR)",

issn = "1097-6647",

publisher = "BioMed Central",

number = "1",

}

Weir-McCall, JR, Lambert, M, Gandy, SJ, Belch, JJF, Cavin, I, Henderson, SA, Littleford, R, Macfarlane, JA, Matthew, SZ, Nicholas, RS, Struthers, AD , Sullivan, F, White, RD & Houston, JG 2018, 'Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study', Journal of Cardiovascular Magnetic Resonance (JCMR), vol. 20, no. 1, 7, pp. 1-11. https://doi.org/10.1186/s12968-018-0428-0

TY - JOUR

T1 - Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis

T2 - a TASCFORCE study

AU - Weir-McCall, Jonathan R.

AU - Lambert, Matthew

AU - Gandy, Stephen J.

AU - Belch, Jill J. F.

AU - Cavin, Ian

AU - Henderson, Shelley A.

AU - Littleford, Roberta

AU - Macfarlane, Jennifer A.

AU - Matthew, Shona Z.

AU - Nicholas, R. Stephen

AU - Struthers, Allan D.

AU - Sullivan, Frank

AU - White, Richard D.

AU - Houston, J. Graeme

N1 - The present study was funded by the Souter Charitable Foundation and the Chest, Heart and Stroke Scotland Charity. The statistician was funded by TENOVUS, Tayside. JRWM is supported by the Wellcome Trust through the Scottish Translational Medicine and Therapeutics Initiative (Grant no. WT 085664) in the form of a Clinical Research Fellowship. Neither group had any role in: study design, the collection, analysis, and interpretation of data; in the writing of the manuscript; nor in the decision to submit the manuscript for publication.

PY - 2018/1/30

Y1 - 2018/1/30

N2 - Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

AB - Background: Arteriosclerosis (arterial stiffening) is associated with future cardiovascular events, with this effect postulated to be due to its effect on cardiac afterload, atherosclerosis (plaque formation) progression or both, but with limited evidence examining these early in disease formation. The aim of the current study is to examine the association between arteriosclerosis, atherosclerosis and ventricular remodelling in a population at low-intermediate cardiovascular risk.Methods: One thousand six hundred fifty-one subjects free of clinical cardiovascular disease and with a < 20% 10 year cardiovascular risk score underwent a cardiovascular magnetic resonance (CMR) study and whole body CMR angiogram. Arteriosclerosis was measured using total arterial compliance (TAC) - calculated as the indexed stroke volume divided by the pulse pressure. Atherosclerosis was quantified using a standardised atheroma score (SAS) which was calculated by scoring 30 arterial segments within the body based on the degree of stenosis, summating these scores and normalising it to the number of assessable segments. Left ventricular remodelling was measured using left ventricular mass to volume ratio (LVMVR).Results: One thousand five hundred fifteen (38% male, 53.8 ± 8.2 years old) completed the study. On univariate analysis TAC was associated with SAS but this was lost after accounting for cardiovascular risk factors in both males (B = - 0.001 (- 0.004-0.002),p = 0.62) and females (B = 0.000(95%CI -0.002--0.002),p = 0.78). In contrast compliance correlated with LVMVR after accounting for cardiovascular risk factors (B = - 0.12(95%CI -0.16--0.091),p < 0.001 in males; B = - 0.12(95%CI -0.15--0.086),p < 0.001 in females).Conclusion: Systemic arteriosclerosis is associated with left ventricular remodelling but not atherosclerosis. Future efforts in cardiovascular risk prevention should thus seek to address both arteriosclerosis and atherosclerosis individually.

KW - Arterial complaince

KW - Arteriosclerosis

KW - Atherosclerosis

KW - Cardiovascular risk

KW - Left ventricle

U2 - 10.1186/s12968-018-0428-0

DO - 10.1186/s12968-018-0428-0

M3 - Article

C2 - 29382349

SN - 1097-6647

VL - 20

SP - 1

EP - 11

JO - Journal of Cardiovascular Magnetic Resonance (JCMR)

JF - Journal of Cardiovascular Magnetic Resonance (JCMR)

IS - 1

M1 - 7

ER -

Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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Belch, Jill

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