Systemic toxic effects of local anaesthetics

Christina Beecroft; Gillian Davies

doi:10.1016/j.mpaic.2015.12.014

Systemic toxic effects of local anaesthetics

Christina Beecroft, Gillian Davies

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Systemic toxicity from local anaesthetic agent use is a rare but potentially life-threatening complication. It most commonly occurs following inadvertent intravascular injection. High plasma levels of local anaesthetic lead to central nervous system and cardiovascular toxicity. Treatment of toxicity is mainly supportive; however, there is now evidence for the use of lipid emulsions in the management of severe local anaesthetic toxicity.

Original language	English
Pages (from-to)	179-181
Number of pages	3
Journal	Anaesthesia and Intensive Care Medicine
Volume	17
Issue number	4
Early online date	23 Feb 2016
DOIs	https://doi.org/10.1016/j.mpaic.2015.12.014
Publication status	Published - Apr 2016

Keywords

Bupivacaine
levobupivacaine
lidocaine
lipid emulsion
toxicity

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Critical Care and Intensive Care Medicine

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10.1016/j.mpaic.2015.12.014

Cite this

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title = "Systemic toxic effects of local anaesthetics",

abstract = "Systemic toxicity from local anaesthetic agent use is a rare but potentially life-threatening complication. It most commonly occurs following inadvertent intravascular injection. High plasma levels of local anaesthetic lead to central nervous system and cardiovascular toxicity. Treatment of toxicity is mainly supportive; however, there is now evidence for the use of lipid emulsions in the management of severe local anaesthetic toxicity.",

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AU - Davies, Gillian

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AB - Systemic toxicity from local anaesthetic agent use is a rare but potentially life-threatening complication. It most commonly occurs following inadvertent intravascular injection. High plasma levels of local anaesthetic lead to central nervous system and cardiovascular toxicity. Treatment of toxicity is mainly supportive; however, there is now evidence for the use of lipid emulsions in the management of severe local anaesthetic toxicity.

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KW - levobupivacaine

KW - lidocaine

KW - lipid emulsion

KW - toxicity

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M3 - Article

AN - SCOPUS:84962173664

SN - 1472-0299

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JO - Anaesthesia and Intensive Care Medicine

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IS - 4

ER -

Systemic toxic effects of local anaesthetics

Abstract

Keywords

ASJC Scopus subject areas

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