Systemic toxic effects of local anaesthetics

Christina Beecroft, Gillian Davies

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Systemic toxicity from local anaesthetic agent use is a rare but potentially life-threatening complication. It most commonly occurs following inadvertent intravascular injection. High plasma levels of local anaesthetic lead to central nervous system and cardiovascular toxicity. Treatment of toxicity is mainly supportive; however, there is now evidence for the use of lipid emulsions in the management of severe local anaesthetic toxicity.

    Original languageEnglish
    Pages (from-to)179-181
    Number of pages3
    JournalAnaesthesia and Intensive Care Medicine
    Issue number4
    Early online date23 Feb 2016
    Publication statusPublished - Apr 2016


    • Bupivacaine
    • levobupivacaine
    • lidocaine
    • lipid emulsion
    • toxicity

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine
    • Critical Care and Intensive Care Medicine


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