Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

Peter Bruce Mark Clarkson, Nigel Mark Wheeldon, Catherine Macleod, Thomas MacLennan MacDonald

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalThe American Journal of Cardiology
Volume75
Issue number2
DOIs
Publication statusPublished - 15 Jan 1995

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Myocardial Contraction
Isoproterenol
Adrenergic Agents
Adrenergic Receptors

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Mark Clarkson, Peter Bruce ; Wheeldon, Nigel Mark ; Macleod, Catherine ; MacDonald, Thomas MacLennan. / Systolic and diastolic effects of beta-adrenergic stimulation in normal humans. In: The American Journal of Cardiology. 1995 ; Vol. 75, No. 2. pp. 206-209.
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Systolic and diastolic effects of beta-adrenergic stimulation in normal humans. / Mark Clarkson, Peter Bruce; Wheeldon, Nigel Mark; Macleod, Catherine; MacDonald, Thomas MacLennan.

In: The American Journal of Cardiology, Vol. 75, No. 2, 15.01.1995, p. 206-209.

Research output: Contribution to journalArticle

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