TY - JOUR
T1 - Systolic and diastolic effects of beta-adrenergic stimulation in normal humans
AU - Mark Clarkson, Peter Bruce
AU - Wheeldon, Nigel Mark
AU - Macleod, Catherine
AU - MacDonald, Thomas MacLennan
PY - 1995/1/15
Y1 - 1995/1/15
N2 - We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.
AB - We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.
UR - http://www.scopus.com/inward/record.url?scp=0028796792&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(00)80084-3
DO - 10.1016/S0002-9149(00)80084-3
M3 - Article
C2 - 7810510
AN - SCOPUS:0028796792
SN - 0002-9149
VL - 75
SP - 206
EP - 209
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 2
ER -