Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

Peter Bruce Mark Clarkson, Nigel Mark Wheeldon, Catherine Macleod, Thomas MacLennan MacDonald

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalThe American Journal of Cardiology
Volume75
Issue number2
DOIs
Publication statusPublished - 15 Jan 1995

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