Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

Peter Bruce Mark Clarkson; Nigel Mark Wheeldon; Catherine Macleod; Thomas MacLennan MacDonald

doi:10.1016/S0002-9149(00)80084-3

Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

Peter Bruce Mark Clarkson
, Nigel Mark Wheeldon
, Catherine Macleod
, Thomas MacLennan MacDonald

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.

Original language	English
Pages (from-to)	206-209
Number of pages	4
Journal	The American Journal of Cardiology
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/S0002-9149(00)80084-3
Publication status	Published - 15 Jan 1995

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(00)80084-3

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title = "Systolic and diastolic effects of beta-adrenergic stimulation in normal humans",

abstract = "We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.",

author = "\{Mark Clarkson\}, \{Peter Bruce\} and Wheeldon, \{Nigel Mark\} and Catherine Macleod and MacDonald, \{Thomas MacLennan\}",

year = "1995",

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doi = "10.1016/S0002-9149(00)80084-3",

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T1 - Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

AU - Mark Clarkson, Peter Bruce

AU - Wheeldon, Nigel Mark

AU - Macleod, Catherine

AU - MacDonald, Thomas MacLennan

PY - 1995/1/15

Y1 - 1995/1/15

N2 - We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.

AB - We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.

UR - https://www.scopus.com/pages/publications/0028796792

U2 - 10.1016/S0002-9149(00)80084-3

DO - 10.1016/S0002-9149(00)80084-3

M3 - Article

C2 - 7810510

AN - SCOPUS:0028796792

SN - 0002-9149

VL - 75

SP - 206

EP - 209

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

IS - 2

ER -

Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

Abstract

ASJC Scopus subject areas

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