Abstract
Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca2+ levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21ras acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.
Original language | English |
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Pages (from-to) | 268-271 |
Number of pages | 4 |
Journal | Trends in Cell Biology |
Volume | 2 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 1992 |
ASJC Scopus subject areas
- Cell Biology