T-cell activation

Manuel Izquierdo, Doreen A. Cantrell

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca2+ levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21ras acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.

    Original languageEnglish
    Pages (from-to)268-271
    Number of pages4
    JournalTrends in Cell Biology
    Volume2
    Issue number9
    DOIs
    Publication statusPublished - Sep 1992

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