T-cell activation

Manuel Izquierdo; Doreen A. Cantrell

doi:10.1016/0962-8924(92)90199-W

T-cell activation

Manuel Izquierdo, Doreen A. Cantrell

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca²⁺ levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21^ras acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.

Original language	English
Pages (from-to)	268-271
Number of pages	4
Journal	Trends in Cell Biology
Volume	2
Issue number	9
DOIs	https://doi.org/10.1016/0962-8924(92)90199-W
Publication status	Published - Sept 1992

ASJC Scopus subject areas

Cell Biology

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10.1016/0962-8924(92)90199-W

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title = "T-cell activation",

abstract = "Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca2+ levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21ras acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.",

author = "Manuel Izquierdo and Cantrell, {Doreen A.}",

year = "1992",

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AU - Izquierdo, Manuel

AU - Cantrell, Doreen A.

PY - 1992/9

Y1 - 1992/9

N2 - Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca2+ levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21ras acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.

AB - Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca2+ levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21ras acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.

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U2 - 10.1016/0962-8924(92)90199-W

DO - 10.1016/0962-8924(92)90199-W

M3 - Article

AN - SCOPUS:0026746146

SN - 0962-8924

VL - 2

SP - 268

EP - 271

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 9

ER -

T-cell activation

Abstract

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