T cell activation and the cytoskeleton

Oreste Acuto (Lead / Corresponding author), Doreen Cantrell (Lead / Corresponding author)

    Research output: Contribution to journalReview article

    213 Citations (Scopus)

    Abstract

    Ligation of the T cell antigen receptor (TCR) stimulates protein tyrosine kinases (PTKs), which regulate intracellular calcium and control the activity of protein kinase C (PKC) isozymes. PTKs activated by antigen receptors and costimulatory molecules also couple to phosphatidylinositol-3 kinase (PI3K) and control the activity of Ras- and Rho-family GTPases. T cell signal transduction is triggered physiologically by antigen in the context of antigen presenting cells (APC). The formation of stable and prolonged contacts between T cells and APCs is not neccessary to initiate T cell signaling but is required for effective T cell proliferation and differentiation. The stabilization of the T cell/APC conjugate is regulated by intracellular signals induced by antigen receptors and costimulators. These coordinate the regulation of the actin and microtubule cytoskeleton and organize a specialized signaling zone that allows sustained TCR signaling.

    Original languageEnglish
    Pages (from-to)165-184
    Number of pages20
    JournalAnnual Review of Immunology
    Volume18
    DOIs
    Publication statusPublished - Apr 2000

    Keywords

    • CD28
    • Protein kinase C
    • Protein tyrosine kinases
    • Rho GTPases
    • T cell antigen receptor

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