T cell antigen receptor signal transduction pathways

Doreen Cantrell (Lead / Corresponding author)

Research output: Contribution to journalReview article

580 Citations (Scopus)

Abstract

The T cell antigen receptor (TCR) regulates the activation and growth of T lymphocytes. The initial membrane proximal event triggered by the TCR is activation of protein tyrosine kinases with the resultant phosphorylation of cellular proteins. This biochemical response couples the TCR to a divergent array of signal transduction molecules including enzymes that regulate lipid metabolism, GTP binding proteins, serine/threonine kinases, and adapter molecules. The ultimate aim of studies of intracellular signaling mechanisms is to understand the functional consequences of a particular biochemical event for receptor function. The control of cytokine gene expression is one of the mechanisms that allows the TCR to control immune responses. Accordingly, one object of the present review is to discuss the role of the different TCR signal transduction pathways in linking the TCR to nuclear targets: the transcription factors that control the expression of cytokine genes.

Original languageEnglish
Pages (from-to)259-274
Number of pages16
JournalAnnual Review of Immunology
Volume14
DOIs
Publication statusPublished - 8 May 1996

Keywords

  • calcium
  • Grb2
  • MAP kinases
  • p21(ras)
  • protein kinaseC
  • T cell antigen receptor

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