T cell antigen receptor signal transduction pathways

TY - JOUR

T1 - T cell antigen receptor signal transduction pathways

AU - Cantrell, D. A.

PY - 1996

Y1 - 1996

N2 - The T cell antigen receptor regulates the activation and growth of T lymphocytes. The initial membrane proximal event triggered by the TCR is activation of protein tyrosine kinases with the resultant phosphorylation of cellular proteins. This biochemical response couples the TCR to a divergent array of signal transduction molecules, including enzymes that regulate lipid metabolism, GTP binding proteins, serine/threonine kinases and adapter molecules. The control of cytokine gene expression is one of the mechanisms that allows the TCR to control immune responses, and this chapter discusses the role of the different TCR signal transduction pathways in linking the TCR to nuclear targets-the transcription factors that control the expression of cytokine genes.

AB - The T cell antigen receptor regulates the activation and growth of T lymphocytes. The initial membrane proximal event triggered by the TCR is activation of protein tyrosine kinases with the resultant phosphorylation of cellular proteins. This biochemical response couples the TCR to a divergent array of signal transduction molecules, including enzymes that regulate lipid metabolism, GTP binding proteins, serine/threonine kinases and adapter molecules. The control of cytokine gene expression is one of the mechanisms that allows the TCR to control immune responses, and this chapter discusses the role of the different TCR signal transduction pathways in linking the TCR to nuclear targets-the transcription factors that control the expression of cytokine genes.

UR - https://www.scopus.com/pages/publications/0029957630

M3 - Review article

C2 - 8909800

AN - SCOPUS:0029957630

SN - 0261-2429

VL - 27

SP - 165

EP - 175

JO - Cancer Surveys

JF - Cancer Surveys

IS - 4

ER -