Nanocomplejos del receptor para el antígeno de linfocitos T: Agruparse para cooperar

Translated title of the contribution: T cell receptor nanocomplexes: Cooperating clusters

Wolfgang W.A. Schamel, Hisse M. Van Santen, Mahima Swamy, Balbino Alarcón (Lead / Corresponding author)

Research output: Contribution to journalReview article

Abstract

The T cell antigen receptor (TCRCD3) is a multi-subunit complex responsible for triggering an adaptive immune response. It shows high specificity and sensitivity while having a low affinity for the ligand. Furthermore, T cells respond to antigen over a wide concentration range. The stoichiometry and architecture of TCR-CD3 in the membrane have been under intense scrutiny because they might be key to explaining its paradoxical properties. This review highlights new evidence that TCR-CD3 is found on intact, unstimulated T cells in monovalent (one ligand-binding site per receptor) as well as in several distinct multivalent forms. This is in contrast to the TCR-CD3 stoichiometries determined by several biochemical means, but these data can be explained by the effects of different detergents on the integrity of the receptor. Here, we discuss a model in which the multivalent receptors are important for the detection of low concentrations of ligand, and therefore confer sensitivity, whereas the co-expressed monovalent TCR-CD3s allow a wide dynamic range.

Translated title of the contributionT cell receptor nanocomplexes: Cooperating clusters
Original languageSpanish
Pages (from-to)727-742
Number of pages16
JournalAnales de la Real Academia Nacional de Farmacia
Volume74
Issue number4
Publication statusPublished - 1 Dec 2008

Keywords

  • Conformational change
  • Signal transduction
  • Stoichiometry
  • T cell antigen receptor
  • Transmembrane interactions

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