T lymphocyte activation signals

D. A. Cantrell, J. D. Graves, M. Izquierdo, S. Lucas, J. Downward

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Activation of T lymphocytes results in immediate biochemical changes including increases in intracellular calcium levels, activation of protein kinase C (PKC) and changes in tyrosine phosphorylation. In T cells recent studies have indicated that activation of the guanine nucleotide-binding proteins p21ras is mediated by PKC, which suggests that the p21ras proteins may regulate intracellular signalling events downstream of PKC. The p21ras proteins can be activated in T cells by signals generated by triggering of the T cell antigen receptor (TCR), the CD2 antigen and the interleukin 2 receptor. Experiments using a PKC pseudosubstrate inhibitor indicate that PKC does not mediate TCR-induced activation of p21ras. These results imply that an alternative signal transduction pathway not involving PKC can regulate the activity of p21ras proteins in T cells.

Original languageEnglish
Pages (from-to)208-218; discussion 218-222
JournalCiba Foundation Symposium
Volume164
DOIs
Publication statusPublished - 1992

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    Cantrell, D. A., Graves, J. D., Izquierdo, M., Lucas, S., & Downward, J. (1992). T lymphocyte activation signals. Ciba Foundation Symposium, 164, 208-218; discussion 218-222. https://doi.org/10.1002/9780470514207.ch13