Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter

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    Abstract

    SUMMARY Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics.
    Original languageEnglish
    Pages (from-to)28-36
    Number of pages9
    JournalParasitology
    Volume141
    Issue number1
    Early online date9 Aug 2013
    DOIs
    Publication statusPublished - Jan 2014

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