Abstract
SUMMARY Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics.
Original language | English |
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Pages (from-to) | 28-36 |
Number of pages | 9 |
Journal | Parasitology |
Volume | 141 |
Issue number | 1 |
Early online date | 9 Aug 2013 |
DOIs | |
Publication status | Published - Jan 2014 |