Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue

Dawn M. Carnell, Rowena E. Smith, Frances M. Daley, Paul R. Barber, Peter J. Hoskin, George D. Wilson, Graeme I. Murray, Steven A. Everett

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    64 Citations (Scopus)

    Abstract

    To investigate the localization and distribution of cytochrome P450 CYP1B1 protein expression in patients diagnosed with prostate carcinoma compared to those with bladder carcinoma. To validate CYP1B1 as a molecular target for the development of selective cancer therapeutics for use in combination with radiation.
    Original languageEnglish
    Pages (from-to)500-509
    Number of pages10
    JournalInternational Journal of Radiation Oncology Biology Physics
    Volume58
    Issue number2
    DOIs
    Publication statusPublished - Feb 2004

    Keywords

    • Cytochrome P450 CYP1B1
    • Prostate carcinoma
    • Bladder carcinoma
    • Radiation
    • Hyperplasia
    • PIN
    • Spectral imaging microscopy

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