Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue

Dawn M. Carnell; Rowena E. Smith; Frances M. Daley; Paul R. Barber; Peter J. Hoskin; George D. Wilson; Graeme I. Murray; Steven A. Everett

doi:10.1016/j.ijrobp.2003.09.064

Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue

Dawn M. Carnell
, Rowena E. Smith
, Frances M. Daley
, Paul R. Barber
, Peter J. Hoskin
, George D. Wilson
, Graeme I. Murray
, Steven A. Everett

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

To investigate the localization and distribution of cytochrome P450 CYP1B1 protein expression in patients diagnosed with prostate carcinoma compared to those with bladder carcinoma. To validate CYP1B1 as a molecular target for the development of selective cancer therapeutics for use in combination with radiation.

Original language	English
Pages (from-to)	500-509
Number of pages	10
Journal	(IJROBP)
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/j.ijrobp.2003.09.064
Publication status	Published - Feb 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytochrome P450 CYP1B1
Prostate carcinoma
Bladder carcinoma
Radiation
Hyperplasia
PIN
Spectral imaging microscopy

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10.1016/j.ijrobp.2003.09.064

Cite this

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title = "Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue",

abstract = "To investigate the localization and distribution of cytochrome P450 CYP1B1 protein expression in patients diagnosed with prostate carcinoma compared to those with bladder carcinoma. To validate CYP1B1 as a molecular target for the development of selective cancer therapeutics for use in combination with radiation.",

keywords = "Cytochrome P450 CYP1B1, Prostate carcinoma, Bladder carcinoma, Radiation, Hyperplasia, PIN, Spectral imaging microscopy",

author = "Carnell, \{Dawn M.\} and Smith, \{Rowena E.\} and Daley, \{Frances M.\} and Barber, \{Paul R.\} and Hoskin, \{Peter J.\} and Wilson, \{George D.\} and Murray, \{Graeme I.\} and Everett, \{Steven A.\}",

note = "dc.publisher: Elsevier ",

year = "2004",

month = feb,

doi = "10.1016/j.ijrobp.2003.09.064",

language = "English",

volume = "58",

pages = "500--509",

journal = "(IJROBP)",

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T1 - Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue

AU - Carnell, Dawn M.

AU - Smith, Rowena E.

AU - Daley, Frances M.

AU - Barber, Paul R.

AU - Hoskin, Peter J.

AU - Wilson, George D.

AU - Murray, Graeme I.

AU - Everett, Steven A.

N1 - dc.publisher: Elsevier

PY - 2004/2

Y1 - 2004/2

N2 - To investigate the localization and distribution of cytochrome P450 CYP1B1 protein expression in patients diagnosed with prostate carcinoma compared to those with bladder carcinoma. To validate CYP1B1 as a molecular target for the development of selective cancer therapeutics for use in combination with radiation.

AB - To investigate the localization and distribution of cytochrome P450 CYP1B1 protein expression in patients diagnosed with prostate carcinoma compared to those with bladder carcinoma. To validate CYP1B1 as a molecular target for the development of selective cancer therapeutics for use in combination with radiation.

KW - Cytochrome P450 CYP1B1

KW - Prostate carcinoma

KW - Bladder carcinoma

KW - Radiation

KW - Hyperplasia

KW - PIN

KW - Spectral imaging microscopy

U2 - 10.1016/j.ijrobp.2003.09.064

DO - 10.1016/j.ijrobp.2003.09.064

M3 - Article

VL - 58

SP - 500

EP - 509

JO - (IJROBP)

JF - (IJROBP)

IS - 2

ER -

Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue

Abstract

UN SDGs

Keywords

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