Target validation

switching domains

Alessio Ciulli (Lead / Corresponding author)

Research output: Contribution to journalShort survey

109 Downloads (Pure)

Abstract

Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.
Original languageEnglish
Pages (from-to)659-660
Number of pages2
JournalNature Chemical Biology
Volume12
Issue number9
Early online date18 Aug 2016
DOIs
Publication statusPublished - Sep 2016

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Pharmacology
Pharmaceutical Preparations
Proteins

Keywords

  • Cancer therapy
  • Chemical genetics
  • Small molecules
  • Target validation
  • Transcription

Cite this

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title = "Target validation: switching domains",
abstract = "Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.",
keywords = "Cancer therapy, Chemical genetics, Small molecules, Target validation, Transcription",
author = "Alessio Ciulli",
year = "2016",
month = "9",
doi = "10.1038/nchembio.2154",
language = "English",
volume = "12",
pages = "659--660",
journal = "Nature Chemical Biology",
issn = "1552-4450",
publisher = "Nature Publishing Group",
number = "9",

}

Target validation : switching domains. / Ciulli, Alessio (Lead / Corresponding author).

In: Nature Chemical Biology, Vol. 12, No. 9, 09.2016, p. 659-660.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Target validation

T2 - switching domains

AU - Ciulli, Alessio

PY - 2016/9

Y1 - 2016/9

N2 - Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.

AB - Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.

KW - Cancer therapy

KW - Chemical genetics

KW - Small molecules

KW - Target validation

KW - Transcription

U2 - 10.1038/nchembio.2154

DO - 10.1038/nchembio.2154

M3 - Short survey

VL - 12

SP - 659

EP - 660

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 9

ER -