Projects per year
Abstract
Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.
Original language | English |
---|---|
Pages (from-to) | 659-660 |
Number of pages | 2 |
Journal | Nature Chemical Biology |
Volume | 12 |
Issue number | 9 |
Early online date | 18 Aug 2016 |
DOIs | |
Publication status | Published - Sep 2016 |
Keywords
- Cancer therapy
- Chemical genetics
- Small molecules
- Target validation
- Transcription
Fingerprint
Dive into the research topics of 'Target validation: switching domains'. Together they form a unique fingerprint.Projects
- 2 Finished