Target validation: switching domains

Alessio Ciulli (Lead / Corresponding author)

Research output: Contribution to journalShort survey

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Abstract

Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.
Original languageEnglish
Pages (from-to)659-660
Number of pages2
JournalNature Chemical Biology
Volume12
Issue number9
Early online date18 Aug 2016
DOIs
Publication statusPublished - Sep 2016

Keywords

  • Cancer therapy
  • Chemical genetics
  • Small molecules
  • Target validation
  • Transcription

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