Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 659-660 |
| Number of pages | 2 |
| Journal | Nature Chemical Biology |
| Volume | 12 |
| Issue number | 9 |
| Early online date | 18 Aug 2016 |
| DOIs | |
| Publication status | Published - Sep 2016 |
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Keywords
- Cancer therapy
- Chemical genetics
- Small molecules
- Target validation
- Transcription
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Target validation : switching domains. / Ciulli, Alessio (Lead / Corresponding author).
In: Nature Chemical Biology, Vol. 12, No. 9, 09.2016, p. 659-660.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Target validation
T2 - switching domains
AU - Ciulli, Alessio
PY - 2016/9
Y1 - 2016/9
N2 - Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.
AB - Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.
KW - Cancer therapy
KW - Chemical genetics
KW - Small molecules
KW - Target validation
KW - Transcription
U2 - 10.1038/nchembio.2154
DO - 10.1038/nchembio.2154
M3 - Short survey
C2 - 27538023
VL - 12
SP - 659
EP - 660
JO - Nature Chemical Biology
JF - Nature Chemical Biology
SN - 1552-4450
IS - 9
ER -