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Targeting a critical step in fungal hexosamine biosynthesis
Deborah Lockhart (Lead / Corresponding author)
,
Mathew Stanley
,
Olawale Raimi
, David Robinson
, Dominika Boldovjakova
, Daniel Squair
, Andrew Ferenbach
, Wenxia Fang
,
Daan van Aalten
(Lead / Corresponding author)
Drug Discovery Unit
MRC PPU
Research output
:
Contribution to journal
›
Article
›
peer-review
16
Citations (Scopus)
113
Downloads (Pure)
Overview
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Projects
(2)
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Dive into the research topics of 'Targeting a critical step in fungal hexosamine biosynthesis'. Together they form a unique fingerprint.
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Keyphrases
Cell Wall
100%
Genetic Evidence
100%
Fungal Cell Wall
100%
Antifungal Targets
100%
Hexosamine Biosynthesis
100%
Chemical Evidence
100%
Mutant Strains
50%
Active Sites
50%
Host Defense
50%
Biosynthesis Enzymes
50%
GlcNAc
50%
Chitin
50%
UDP-GlcNAc
50%
Extracellular Environment
50%
Fumigatus
50%
Aspergillus Fumigatus
50%
Binder
50%
Glucosamine-6-phosphate N-acetyltransferase
50%
Murine Model
50%
Aspergillosis
50%
Antifungal Drugs
50%
Cell Wall Integrity
50%
Fragment-based Approach
50%
Hexosamine Pathway
50%
Attenuated Virulence
50%
Fungal Viability
50%
Opportunistic Fungal Pathogen
50%
Heterocyclic Scaffolds
50%
Biochemistry, Genetics and Molecular Biology
Enzyme
100%
Anabolism
100%
Hexosamine
100%
Genetics
66%
Fungal Cell Wall
66%
Active Site
33%
Infectious Agent
33%
Host Resistance
33%
Uridine Diphosphate
33%
N-Acetyltransferase
33%
Aspergillus fumigatus
33%
Fungal Viability
33%
Chitin
33%
Glucosamine
33%
Medicine and Dentistry
Hexosamine
100%
Antifungal Agent
66%
Cell Wall
66%
Fungal Cell Wall
66%
Pathogen
33%
Acyltransferase
33%
Uridine Diphosphate
33%
Glucosamine
33%
Chitin
33%
Host Resistance
33%
Aspergillus fumigatus
33%
Fungal Viability
33%
Aspergillosis
33%
Immunology and Microbiology
Cell Wall
100%
Fungal Cell Wall
100%
Infectious Agent
50%
Host Resistance
50%
Aspergillus fumigatus
50%
Fungal Viability
50%
Pharmacology, Toxicology and Pharmaceutical Science
Hexosamine
100%
Antifungal Agent
66%
Infectious Agent
33%
Uridine Diphosphate
33%
Glucosamine
33%
Aspergillus fumigatus
33%
Chitin
33%
Acyltransferase
33%
Aspergillosis
33%