Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

Keyphrases

• Drug Discovery 100%
• E3 Ubiquitin Ligase 100%
• Small Molecules 100%
• Cullin-RING E3 Ligase 100%
• Component Size 50%
• Biological Processes 50%
• Oncogene 50%
• Small Molecule Inhibitors 50%
• Therapeutic Targeting 50%
• Large Families 50%
• Tumor Suppressor 50%
• Substrate Specificity 50%
• Cullin 50%
• Structure-based Design 50%
• Adaptor 50%
• Human Disease 50%
• Novel Therapeutics 50%
• Ubiquitin-proteasome System 50%
• State of the Field 50%
• Chemical Probes 50%
• Ubiquitin System 50%
• Substrate Receptors 50%
• Multisubunit Complexes 50%
• Substrate Peptide 50%
• Full-size 50%
• Rational Structure 50%
• Chemical Potential 50%
• CRL Complex 50%
• Small Molecule Peptide 50%
• Small Molecule Therapeutics 50%
• Small Molecule Modulators 50%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Ubiquitin-Conjugating Enzyme 100%
• Cullin 100%
• Biological Phenomena and Functions Concerning the Entire Organism 25%
• Enzyme 25%
• Crystal Structure 25%
• Tumor Suppressor Protein 25%
• Enzyme Specificity 25%
• Ubiquitin 25%
• Oncogene 25%
• Multisubunit-Complex 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Drug Discovery 100%
• Ubiquitin Protein Ligase E3 100%
• Cullin 100%
• Malignant Neoplasm 33%
• Receptor 33%
• Tumor Suppressor Protein 33%
• Substrate Specificity 33%
• Ubiquitin 33%
• Diseases 33%