Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure

Abbey Steggall, Ify Mordi, Chim Lang (Lead / Corresponding author)

Research output: Contribution to journalReview article

212 Downloads (Pure)

Abstract

Despite significant improvements in morbidity and mortality with current evidence-based pharmaceutical-based treatment of heart failure (HF) over the previous decades, the burden of HF remains high. An alternative approach is currently being developed, which targets myocardial energy efficiency and the dysfunction of the cardiac mitochondria. Emerging evidence suggests that the insufficient availability of ATP to the failing myocardium can be attributed to abnormalities in the myocardial utilisation of its substrates rather than an overall lack of substrate availability. Therefore, the development of potential metabolic therapeutics has commenced including trimetazidine, ranolazine and perhexiline, as well as specific mitochondrial-targeting pharmaceuticals, such as elamipretide. Large randomised controlled trials are required to confirm the role of metabolic-modulating drugs in the treatment of heart failure, but early studies have been promising in their possible efficacy for the management of heart failure in the future.
Original languageEnglish
Article number14
Pages (from-to)1-18
Number of pages18
JournalDiseases
Volume5
Issue number2
DOIs
Publication statusPublished - 10 May 2017

Keywords

  • heart failure
  • metabolic
  • mitochondria
  • trimetazidine
  • ranolazine
  • perhexiline
  • elamipretide

Fingerprint Dive into the research topics of 'Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure'. Together they form a unique fingerprint.

  • Cite this