Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma

Silvia Pietrobono (Lead / Corresponding author), Eugenio Gaudio, Sinforosa Gagliardi, Mariapaola Zitani, Laura Carrassa, Francesca Migliorini, Elena Petricci, Fabrizio Manetti, Nikolai Makukhin, Adam G. Bond, Brooke D. Paradise, Alessio Ciulli, Martin E. Fernandez-Zapico, Francesco Bertoni, Barbara Stecca (Lead / Corresponding author)

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

22 Downloads (Pure)

1 Active
2 Finished

3 results

Active
Novel PROTAC-based Chemical Biology Approaches to Induced Protein Knockdown Across the Proteome (PhD Studentship - with Boehringer Ingelheim)
Ciulli, A. & Sapkota, G.
3/09/18 → 2/09/22
Project: Research
Finished
DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)
Ciulli, A.
COMMISSION OF THE EUROPEAN COMMUNITIES
1/05/13 → 30/04/18
Project: Research
A Systems Approach for the Fragment-based Development of Selective Chemical Probes of Bromodomain Function (joint with University of Oxford)
Ciulli, A.
Biotechnology and Biological Sciences Research Council
8/04/13 → 7/06/15
Project: Research