Targeting of proteins to the twin-arginine translocation pathway

Tracy Palmer (Lead / Corresponding author), Phillip J. Stansfeld

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)
4 Downloads (Pure)

Abstract

The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation.

Original languageEnglish
Pages (from-to)861-871
Number of pages11
JournalMolecular Microbiology
Volume113
Issue number5
Early online date23 Jan 2020
DOIs
Publication statusPublished - May 2020

Keywords

  • folded protein
  • mechanism
  • protein transport
  • Tat pathway
  • twin-arginine signal peptide

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