Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery

D. M. Baker; J. A. Jones; J S Nguyen-Van-Tam; J H Lloyd; D L Morris; J B Bourke; R. J. C. Steele; J D Hardcastle

Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery

D. M. Baker, J. A. Jones, J S Nguyen-Van-Tam, J H Lloyd, D L Morris, J B Bourke, R. J. C. Steele, J D Hardcastle

Research output: Contribution to journal › Article › peer-review

Abstract

A total of 300 patients undergoing elective colorectal surgery over a 3-year period were randomly assigned to receive intraoperative peritoneal lavage with either taurolidine or saline. Culture swabs were taken from the region of surgery before and after lavage and the development of postoperative infection monitored. Of the positive culture swabs before lavage, a significantly higher proportion were negative after lavage with taurolidine than after that with saline. However, there was no difference in the incidence of postoperative infection between groups, suggesting that taurolidine intraoperative peritoneal lavage confers no clinical benefit over that with saline.

Original language	English
Pages (from-to)	1054-1056
Number of pages	3
Journal	British Journal of Surgery
Volume	81
Issue number	7
Publication status	Published - 1994

Keywords

Anti-Infective Agents, Local
Colon
Female
Humans
Intraoperative Care
Male
Middle Aged
Peritoneal Lavage
Rectum
Surgical Procedures, Elective
Surgical Wound Infection
Taurine
Thiadiazines

Cite this

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title = "Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery",

abstract = "A total of 300 patients undergoing elective colorectal surgery over a 3-year period were randomly assigned to receive intraoperative peritoneal lavage with either taurolidine or saline. Culture swabs were taken from the region of surgery before and after lavage and the development of postoperative infection monitored. Of the positive culture swabs before lavage, a significantly higher proportion were negative after lavage with taurolidine than after that with saline. However, there was no difference in the incidence of postoperative infection between groups, suggesting that taurolidine intraoperative peritoneal lavage confers no clinical benefit over that with saline.",

keywords = "Anti-Infective Agents, Local, Colon, Female, Humans, Intraoperative Care, Male, Middle Aged, Peritoneal Lavage, Rectum, Surgical Procedures, Elective, Surgical Wound Infection, Taurine, Thiadiazines",

author = "Baker, {D. M.} and Jones, {J. A.} and Nguyen-Van-Tam, {J S} and Lloyd, {J H} and Morris, {D L} and Bourke, {J B} and Steele, {R. J. C.} and Hardcastle, {J D}",

year = "1994",

language = "English",

volume = "81",

pages = "1054--1056",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "Wiley",

number = "7",

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TY - JOUR

T1 - Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery

AU - Baker, D. M.

AU - Jones, J. A.

AU - Nguyen-Van-Tam, J S

AU - Lloyd, J H

AU - Morris, D L

AU - Bourke, J B

AU - Steele, R. J. C.

AU - Hardcastle, J D

PY - 1994

Y1 - 1994

N2 - A total of 300 patients undergoing elective colorectal surgery over a 3-year period were randomly assigned to receive intraoperative peritoneal lavage with either taurolidine or saline. Culture swabs were taken from the region of surgery before and after lavage and the development of postoperative infection monitored. Of the positive culture swabs before lavage, a significantly higher proportion were negative after lavage with taurolidine than after that with saline. However, there was no difference in the incidence of postoperative infection between groups, suggesting that taurolidine intraoperative peritoneal lavage confers no clinical benefit over that with saline.

AB - A total of 300 patients undergoing elective colorectal surgery over a 3-year period were randomly assigned to receive intraoperative peritoneal lavage with either taurolidine or saline. Culture swabs were taken from the region of surgery before and after lavage and the development of postoperative infection monitored. Of the positive culture swabs before lavage, a significantly higher proportion were negative after lavage with taurolidine than after that with saline. However, there was no difference in the incidence of postoperative infection between groups, suggesting that taurolidine intraoperative peritoneal lavage confers no clinical benefit over that with saline.

KW - Anti-Infective Agents, Local

KW - Colon

KW - Female

KW - Humans

KW - Intraoperative Care

KW - Male

KW - Middle Aged

KW - Peritoneal Lavage

KW - Rectum

KW - Surgical Procedures, Elective

KW - Surgical Wound Infection

KW - Taurine

KW - Thiadiazines

M3 - Article

C2 - 7922063

SN - 0007-1323

VL - 81

SP - 1054

EP - 1056

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 7

ER -

Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery

Abstract

Keywords

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