Technical assessment of whole body angiography and cardiac function within a single MRI examination

S. J. Gandy (Lead / Corresponding author), M. Lambert, J. J. F. Belch, I. D. Cavin, E. Crowe, R. Littleford, J. A. Macfarlane, S. Z. Matthew, P. Martin, R. S. Nicholas, A. D. Struthers, F. Sullivan, S. A. Waugh, R. D. White, J. R. Weir-McCall, J. G. Houston

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    Abstract

    AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.

    MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.

    RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.

    CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

    Original languageEnglish
    Pages (from-to)595-603
    Number of pages9
    JournalClinical Radiology
    Volume70
    Issue number6
    Early online date16 Mar 2015
    DOIs
    Publication statusPublished - Jun 2015

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    Heart Ventricles
    Angiography
    Volunteers
    Lower Extremity
    Magnetic Resonance Angiography
    Gadolinium
    Pelvis
    Abdomen
    Pathologic Constriction
    Neck
    Cardiovascular Diseases
    Thorax
    Head

    Cite this

    Gandy, S. J. ; Lambert, M. ; Belch, J. J. F. ; Cavin, I. D. ; Crowe, E. ; Littleford, R. ; Macfarlane, J. A. ; Matthew, S. Z. ; Martin, P. ; Nicholas, R. S. ; Struthers, A. D. ; Sullivan, F. ; Waugh, S. A. ; White, R. D. ; Weir-McCall, J. R. ; Houston, J. G. / Technical assessment of whole body angiography and cardiac function within a single MRI examination. In: Clinical Radiology. 2015 ; Vol. 70, No. 6. pp. 595-603.
    @article{fec62ca001ea491b8aa49e3293576fe7,
    title = "Technical assessment of whole body angiography and cardiac function within a single MRI examination",
    abstract = "AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV {"}late gadolinium enhancement{"} assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8{\%} and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7{\%} and from 9-12 g for LVM. Interobserver repeatability was 8.1{\%} for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6{\%} of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7{\%} of 1488 vessel segments assessed.CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.",
    author = "Gandy, {S. J.} and M. Lambert and Belch, {J. J. F.} and Cavin, {I. D.} and E. Crowe and R. Littleford and Macfarlane, {J. A.} and Matthew, {S. Z.} and P. Martin and Nicholas, {R. S.} and Struthers, {A. D.} and F. Sullivan and Waugh, {S. A.} and White, {R. D.} and Weir-McCall, {J. R.} and Houston, {J. G.}",
    note = "Copyright {\circledC} 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.",
    year = "2015",
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    doi = "10.1016/j.crad.2015.02.003",
    language = "English",
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    Gandy, SJ, Lambert, M, Belch, JJF, Cavin, ID, Crowe, E, Littleford, R, Macfarlane, JA, Matthew, SZ, Martin, P, Nicholas, RS, Struthers, AD, Sullivan, F, Waugh, SA, White, RD, Weir-McCall, JR & Houston, JG 2015, 'Technical assessment of whole body angiography and cardiac function within a single MRI examination', Clinical Radiology, vol. 70, no. 6, pp. 595-603. https://doi.org/10.1016/j.crad.2015.02.003

    Technical assessment of whole body angiography and cardiac function within a single MRI examination. / Gandy, S. J. (Lead / Corresponding author); Lambert, M.; Belch, J. J. F.; Cavin, I. D.; Crowe, E.; Littleford, R.; Macfarlane, J. A.; Matthew, S. Z.; Martin, P.; Nicholas, R. S.; Struthers, A. D.; Sullivan, F.; Waugh, S. A.; White, R. D.; Weir-McCall, J. R.; Houston, J. G.

    In: Clinical Radiology, Vol. 70, No. 6, 06.2015, p. 595-603.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Technical assessment of whole body angiography and cardiac function within a single MRI examination

    AU - Gandy, S. J.

    AU - Lambert, M.

    AU - Belch, J. J. F.

    AU - Cavin, I. D.

    AU - Crowe, E.

    AU - Littleford, R.

    AU - Macfarlane, J. A.

    AU - Matthew, S. Z.

    AU - Martin, P.

    AU - Nicholas, R. S.

    AU - Struthers, A. D.

    AU - Sullivan, F.

    AU - Waugh, S. A.

    AU - White, R. D.

    AU - Weir-McCall, J. R.

    AU - Houston, J. G.

    N1 - Copyright © 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

    PY - 2015/6

    Y1 - 2015/6

    N2 - AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

    AB - AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

    U2 - 10.1016/j.crad.2015.02.003

    DO - 10.1016/j.crad.2015.02.003

    M3 - Article

    C2 - 25791202

    VL - 70

    SP - 595

    EP - 603

    JO - Clinical Radiology

    JF - Clinical Radiology

    SN - 0009-9260

    IS - 6

    ER -