Technical assessment of whole body angiography and cardiac function within a single MRI examination

S. J. Gandy; M. Lambert; J. J. F. Belch; I. D. Cavin; E. Crowe; R. Littleford; J. A. Macfarlane; S. Z. Matthew; P. Martin; R. S. Nicholas; A. D. Struthers; F. Sullivan; S. A. Waugh; R. D. White; J. R. Weir-McCall; J. G. Houston

doi:10.1016/j.crad.2015.02.003

Technical assessment of whole body angiography and cardiac function within a single MRI examination

S. J. Gandy (Lead / Corresponding author), M. Lambert, J. J. F. Belch, I. D. Cavin, E. Crowe, R. Littleford, J. A. Macfarlane, S. Z. Matthew, P. Martin, R. S. Nicholas, A. D. Struthers, F. Sullivan, S. A. Waugh, R. D. White, J. R. Weir-McCall, J. G. Houston

Research output: Contribution to journal › Article › peer-review

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Abstract

AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.

MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.

RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.

CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

Original language	English
Pages (from-to)	595-603
Number of pages	9
Journal	Clinical Radiology
Volume	70
Issue number	6
Early online date	16 Mar 2015
DOIs	https://doi.org/10.1016/j.crad.2015.02.003
Publication status	Published - Jun 2015

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10.1016/j.crad.2015.02.003

Using B-type natriuretic peptide and whole body contrast enhanced magnetic resonance imaging to detect asymptomatic cardiovascular disease and improve prediction of risk of cardiovascular disease: the TASCFORCE Study
Lambert, M. A. (Author), Belch, J. (Supervisor) & Houston, J. (Supervisor), 2016
Student thesis: Doctoral Thesis › Doctor of Medicine

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Gandy, S. J., Lambert, M., Belch, J. J. F., Cavin, I. D., Crowe, E., Littleford, R., Macfarlane, J. A., Matthew, S. Z., Martin, P., Nicholas, R. S., Struthers, A. D., Sullivan, F., Waugh, S. A., White, R. D., Weir-McCall, J. R., & Houston, J. G. (2015). Technical assessment of whole body angiography and cardiac function within a single MRI examination. Clinical Radiology, 70(6), 595-603. https://doi.org/10.1016/j.crad.2015.02.003

@article{fec62ca001ea491b8aa49e3293576fe7,

title = "Technical assessment of whole body angiography and cardiac function within a single MRI examination",

abstract = "AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV {"}late gadolinium enhancement{"} assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.",

author = "Gandy, {S. J.} and M. Lambert and Belch, {J. J. F.} and Cavin, {I. D.} and E. Crowe and R. Littleford and Macfarlane, {J. A.} and Matthew, {S. Z.} and P. Martin and Nicholas, {R. S.} and Struthers, {A. D.} and F. Sullivan and Waugh, {S. A.} and White, {R. D.} and Weir-McCall, {J. R.} and Houston, {J. G.}",

year = "2015",

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doi = "10.1016/j.crad.2015.02.003",

language = "English",

volume = "70",

pages = "595--603",

journal = "Clinical Radiology",

issn = "0009-9260",

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Gandy, SJ, Lambert, M, Belch, JJF, Cavin, ID, Crowe, E, Littleford, R, Macfarlane, JA, Matthew, SZ, Martin, P, Nicholas, RS, Struthers, AD, Sullivan, F, Waugh, SA, White, RD, Weir-McCall, JR & Houston, JG 2015, 'Technical assessment of whole body angiography and cardiac function within a single MRI examination', Clinical Radiology, vol. 70, no. 6, pp. 595-603. https://doi.org/10.1016/j.crad.2015.02.003

TY - JOUR

T1 - Technical assessment of whole body angiography and cardiac function within a single MRI examination

AU - Gandy, S. J.

AU - Lambert, M.

AU - Belch, J. J. F.

AU - Cavin, I. D.

AU - Crowe, E.

AU - Littleford, R.

AU - Macfarlane, J. A.

AU - Matthew, S. Z.

AU - Martin, P.

AU - Nicholas, R. S.

AU - Struthers, A. D.

AU - Sullivan, F.

AU - Waugh, S. A.

AU - White, R. D.

AU - Weir-McCall, J. R.

AU - Houston, J. G.

PY - 2015/6

Y1 - 2015/6

N2 - AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

AB - AIM: To evaluate a combined protocol for simultaneous cardiac MRI (CMR) and contrast-enhanced (CE) whole-body MR angiography (WB-MRA) techniques within a single examination.MATERIALS AND METHODS: Asymptomatic volunteers (n = 48) with low-moderate risk of cardiovascular disease (CVD) were recruited. The protocol was divided into four sections: (1) CMR of left ventricle (LV) structure and function; (2) CE-MRA of the head, neck, and thorax followed by the distal lower limbs; (3) CMR LV "late gadolinium enhancement" assessment; and (4) CE-MRA of the abdomen and pelvis followed by the proximal lower limbs. Multiple observers undertook the image analysis.RESULTS: For CMR, the mean ejection fraction (EF) was 67.3 ± 4.8% and mean left ventricular mass (LVM) was 100.3 ± 22.8 g. The intra-observer repeatability for EF ranged from 2.1-4.7% and from 9-12 g for LVM. Interobserver repeatability was 8.1% for EF and 19.1 g for LVM. No LV delayed myocardial enhancement was observed. For WB-MRA, some degree of luminal narrowing or stenosis was seen at 3.6% of the vessel segments (involving n = 29 of 48 volunteers) and interobserver radiological opinion was consistent in 96.7% of 1488 vessel segments assessed.CONCLUSION: Combined assessment of WB-MRA and CMR can be undertaken within a single examination on a clinical MRI system. The associated analysis techniques are repeatable and may be suitable for larger-scale cardiovascular MRI studies.

U2 - 10.1016/j.crad.2015.02.003

DO - 10.1016/j.crad.2015.02.003

M3 - Article

C2 - 25791202

SN - 0009-9260

VL - 70

SP - 595

EP - 603

JO - Clinical Radiology

JF - Clinical Radiology

IS - 6

ER -

Technical assessment of whole body angiography and cardiac function within a single MRI examination

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Using B-type natriuretic peptide and whole body contrast enhanced magnetic resonance imaging to detect asymptomatic cardiovascular disease and improve prediction of risk of cardiovascular disease: the TASCFORCE Study

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