Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

Albert Tenesa; Evropi Theodoratou; Farhat V. N. Din; Susan M. Farrington; Roseanne Cetnarskyj; Rebecca A. Barnetson; Mary E. Porteous; Harry Campbell; Malcolm G. Dunlop

doi:10.1158/1078-0432.CCR-10-0439

Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

Albert Tenesa, Evropi Theodoratou, Farhat V. N. Din, Susan M. Farrington, Roseanne Cetnarskyj, Rebecca A. Barnetson, Mary E. Porteous, Harry Campbell, Malcolm G. Dunlop (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.

Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.

Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.

Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

Original language	English
Pages (from-to)	3754-3759
Number of pages	6
Journal	Clinical Cancer Research
Volume	16
Issue number	14
Early online date	13 Jul 2010
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-0439
Publication status	Published - Jul 2010

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1078-0432.CCR-10-0439

Cite this

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title = "Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis",

abstract = "Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.",

author = "Albert Tenesa and Evropi Theodoratou and Din, {Farhat V. N.} and Farrington, {Susan M.} and Roseanne Cetnarskyj and Barnetson, {Rebecca A.} and Porteous, {Mary E.} and Harry Campbell and Dunlop, {Malcolm G.}",

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T1 - Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

AU - Tenesa, Albert

AU - Theodoratou, Evropi

AU - Din, Farhat V. N.

AU - Farrington, Susan M.

AU - Cetnarskyj, Roseanne

AU - Barnetson, Rebecca A.

AU - Porteous, Mary E.

AU - Campbell, Harry

AU - Dunlop, Malcolm G.

PY - 2010/7

Y1 - 2010/7

N2 - Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

AB - Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

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Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

Abstract

ASJC Scopus subject areas

UN SDGs

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