Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

Albert Tenesa, Evropi Theodoratou, Farhat V. N. Din, Susan M. Farrington, Roseanne Cetnarskyj, Rebecca A. Barnetson, Mary E. Porteous, Harry Campbell, Malcolm G. Dunlop (Lead / Corresponding author)

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.

    Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.

    Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.

    Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

    Original languageEnglish
    Pages (from-to)3754-3759
    Number of pages6
    JournalClinical Cancer Research
    Volume16
    Issue number14
    Early online date13 Jul 2010
    DOIs
    Publication statusPublished - Jul 2010

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