Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

TY - JOUR

T1 - Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis

AU - Tenesa, Albert

AU - Theodoratou, Evropi

AU - Din, Farhat V. N.

AU - Farrington, Susan M.

AU - Cetnarskyj, Roseanne

AU - Barnetson, Rebecca A.

AU - Porteous, Mary E.

AU - Campbell, Harry

AU - Dunlop, Malcolm G.

PY - 2010/7

Y1 - 2010/7

N2 - Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

AB - Purpose: To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.Experimental Design: To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.Results: None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.Conclusions: We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

UR - https://www.scopus.com/pages/publications/77954722923

U2 - 10.1158/1078-0432.CCR-10-0439

DO - 10.1158/1078-0432.CCR-10-0439

M3 - Article

C2 - 20628028

AN - SCOPUS:77954722923

SN - 1078-0432

VL - 16

SP - 3754

EP - 3759

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 14

ER -