Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study

Camice J. Revier (Lead / Corresponding author), Ulrich Reininghaus, Rina Dutta, Paul Fearon, Robin M. Murray, Gillian A. Doody, Tim Croudace, Paola Dazzan, Margaret Heslin, Adanna Onyejiaka, Eugenia Kravariti, Julia Lappin, Ben Lomas, James B. Kirkbride, Kim Donoghue, Craig Morgan, Peter B. Jones

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Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

Original languageEnglish
Pages (from-to)379-386
Number of pages8
JournalJournal of Nervous and Mental Disease
Volume203
Issue number5
DOIs
Publication statusPublished - May 2015

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Keywords

  • Course and outcome
  • Psychosis
  • Recovery
  • Risk factors
  • Schizophrenia

Cite this

Revier, C. J., Reininghaus, U., Dutta, R., Fearon, P., Murray, R. M., Doody, G. A., Croudace, T., Dazzan, P., Heslin, M., Onyejiaka, A., Kravariti, E., Lappin, J., Lomas, B., Kirkbride, J. B., Donoghue, K., Morgan, C., & Jones, P. B. (2015). Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study. Journal of Nervous and Mental Disease, 203(5), 379-386. https://doi.org/10.1097/NMD.0000000000000295