Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study

Camice J. Revier (Lead / Corresponding author), Ulrich Reininghaus, Rina Dutta, Paul Fearon, Robin M. Murray, Gillian A. Doody, Tim Croudace, Paola Dazzan, Margaret Heslin, Adanna Onyejiaka, Eugenia Kravariti, Julia Lappin, Ben Lomas, James B. Kirkbride, Kim Donoghue, Craig Morgan, Peter B. Jones

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

Original languageEnglish
Pages (from-to)379-386
Number of pages8
JournalJournal of Nervous and Mental Disease
Volume203
Issue number5
DOIs
Publication statusPublished - May 2015

Fingerprint

Psychotic Disorders
Mortality
Multicenter Studies
Schizophrenia
Research Personnel

Keywords

  • Course and outcome
  • Psychosis
  • Recovery
  • Risk factors
  • Schizophrenia

Cite this

Revier, C. J., Reininghaus, U., Dutta, R., Fearon, P., Murray, R. M., Doody, G. A., ... Jones, P. B. (2015). Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study. Journal of Nervous and Mental Disease, 203(5), 379-386. https://doi.org/10.1097/NMD.0000000000000295
Revier, Camice J. ; Reininghaus, Ulrich ; Dutta, Rina ; Fearon, Paul ; Murray, Robin M. ; Doody, Gillian A. ; Croudace, Tim ; Dazzan, Paola ; Heslin, Margaret ; Onyejiaka, Adanna ; Kravariti, Eugenia ; Lappin, Julia ; Lomas, Ben ; Kirkbride, James B. ; Donoghue, Kim ; Morgan, Craig ; Jones, Peter B. / Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study. In: Journal of Nervous and Mental Disease. 2015 ; Vol. 203, No. 5. pp. 379-386.
@article{c593af1020cb4df7809b5feb35690af9,
title = "Ten-year outcomes of first-episode psychoses in the MRC {\AE}sOP-10 study",
abstract = "It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the {\AE}SOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90{\%} when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.",
keywords = "Course and outcome, Psychosis, Recovery, Risk factors, Schizophrenia",
author = "Revier, {Camice J.} and Ulrich Reininghaus and Rina Dutta and Paul Fearon and Murray, {Robin M.} and Doody, {Gillian A.} and Tim Croudace and Paola Dazzan and Margaret Heslin and Adanna Onyejiaka and Eugenia Kravariti and Julia Lappin and Ben Lomas and Kirkbride, {James B.} and Kim Donoghue and Craig Morgan and Jones, {Peter B.}",
year = "2015",
month = "5",
doi = "10.1097/NMD.0000000000000295",
language = "English",
volume = "203",
pages = "379--386",
journal = "Journal of Nervous and Mental Disease",
issn = "0022-3018",
publisher = "Lippincott, Williams & Wilkins",
number = "5",

}

Revier, CJ, Reininghaus, U, Dutta, R, Fearon, P, Murray, RM, Doody, GA, Croudace, T, Dazzan, P, Heslin, M, Onyejiaka, A, Kravariti, E, Lappin, J, Lomas, B, Kirkbride, JB, Donoghue, K, Morgan, C & Jones, PB 2015, 'Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study', Journal of Nervous and Mental Disease, vol. 203, no. 5, pp. 379-386. https://doi.org/10.1097/NMD.0000000000000295

Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study. / Revier, Camice J. (Lead / Corresponding author); Reininghaus, Ulrich; Dutta, Rina; Fearon, Paul; Murray, Robin M.; Doody, Gillian A.; Croudace, Tim; Dazzan, Paola; Heslin, Margaret; Onyejiaka, Adanna; Kravariti, Eugenia; Lappin, Julia; Lomas, Ben; Kirkbride, James B.; Donoghue, Kim; Morgan, Craig; Jones, Peter B.

In: Journal of Nervous and Mental Disease, Vol. 203, No. 5, 05.2015, p. 379-386.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study

AU - Revier, Camice J.

AU - Reininghaus, Ulrich

AU - Dutta, Rina

AU - Fearon, Paul

AU - Murray, Robin M.

AU - Doody, Gillian A.

AU - Croudace, Tim

AU - Dazzan, Paola

AU - Heslin, Margaret

AU - Onyejiaka, Adanna

AU - Kravariti, Eugenia

AU - Lappin, Julia

AU - Lomas, Ben

AU - Kirkbride, James B.

AU - Donoghue, Kim

AU - Morgan, Craig

AU - Jones, Peter B.

PY - 2015/5

Y1 - 2015/5

N2 - It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

AB - It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.

KW - Course and outcome

KW - Psychosis

KW - Recovery

KW - Risk factors

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84929353655&partnerID=8YFLogxK

U2 - 10.1097/NMD.0000000000000295

DO - 10.1097/NMD.0000000000000295

M3 - Article

C2 - 25900547

AN - SCOPUS:84929353655

VL - 203

SP - 379

EP - 386

JO - Journal of Nervous and Mental Disease

JF - Journal of Nervous and Mental Disease

SN - 0022-3018

IS - 5

ER -

Revier CJ, Reininghaus U, Dutta R, Fearon P, Murray RM, Doody GA et al. Ten-year outcomes of first-episode psychoses in the MRC ÆsOP-10 study. Journal of Nervous and Mental Disease. 2015 May;203(5):379-386. https://doi.org/10.1097/NMD.0000000000000295