TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

Martin Griffin, Zhuo Wang, Thomas Thibault, Colin Murdoch, Daniel Rathbone

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The role of TG2 in fibrosis is reported to be related to two important effects. The first in mediating the deposition and accumulation of the fibrotic extracellular matrix (ECM) via its cross-linking of proteins like fibronectin, collagen I and collagen III; and the second, the activation of latent matrix bound TGFβ1. We report here that the role of TG2 in fibrosis progression can be much more complex. We also report a new family of TG2-specific inhibitors that can not only inhibit protein cross-linking, but also regulate other functions of TG2, thus increasing their potency which can be demonstrated by their effectiveness in inhibiting fibrosis in two different fibrotic in vivo models.
    Original languageEnglish
    Pages (from-to)1629
    Number of pages1
    JournalAmino Acids
    Volume47
    Issue number8
    DOIs
    Publication statusPublished - Aug 2015

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