TY - JOUR
T1 - TGF-β in tolerance, development and regulation of immunity
AU - Johnston, Chris J.C.
AU - Smyth, Danielle J.
AU - Dresser, David W.
AU - Maizels, Rick M.
PY - 2016/1
Y1 - 2016/1
N2 - The TGF-β superfamily is an ancient metazoan protein class which cuts across cell and tissue differentiation, developmental biology and immunology. Its many members are regulated at multiple levels from intricate control of gene transcription, post-translational processing and activation, and signaling through overlapping receptor structures and downstream intracellular messengers. We have been interested in TGF-β homologues firstly as key players in the induction of immunological tolerance, the topic so closely associated with Ray Owen. Secondly, our interests in how parasites may manipulate the immune system of their host has also brought us to study the TGF-β pathway in infections with longlived, essentially tolerogenic, helminth parasites. Finally, within the spectrum of mammalian TGF-β proteins is an exquisitely tightly-regulated gene, anti-Müllerian hormone (AMH), whose role in sex determination underpins the phenotype of freemartin calves that formed the focus of Ray's seminal work on immunological tolerance.
AB - The TGF-β superfamily is an ancient metazoan protein class which cuts across cell and tissue differentiation, developmental biology and immunology. Its many members are regulated at multiple levels from intricate control of gene transcription, post-translational processing and activation, and signaling through overlapping receptor structures and downstream intracellular messengers. We have been interested in TGF-β homologues firstly as key players in the induction of immunological tolerance, the topic so closely associated with Ray Owen. Secondly, our interests in how parasites may manipulate the immune system of their host has also brought us to study the TGF-β pathway in infections with longlived, essentially tolerogenic, helminth parasites. Finally, within the spectrum of mammalian TGF-β proteins is an exquisitely tightly-regulated gene, anti-Müllerian hormone (AMH), whose role in sex determination underpins the phenotype of freemartin calves that formed the focus of Ray's seminal work on immunological tolerance.
KW - Infection
KW - Tolerance
KW - Transforming growth factor
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=84947983240&partnerID=8YFLogxK
U2 - 10.1016/j.cellimm.2015.10.006
DO - 10.1016/j.cellimm.2015.10.006
M3 - Article
C2 - 26617281
AN - SCOPUS:84947983240
SN - 0008-8749
VL - 299
SP - 14
EP - 22
JO - Cellular Immunology
JF - Cellular Immunology
ER -