Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices

Jenni Harvey (Lead / Corresponding author), Graham L. Collingridge

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Experiments were performed to investigate whether intact intracellular Ca2+ pools are necessary for long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Thapsigargin (1 μM), which depletes most intracellular Ca2+ pools by blocking ATP-dependent Ca2+ uptake into intracellular compartments, blocked the induction but not the expression of LTP. Thapsigargin had no effect on synaptic transmission or on responses mediated by N-methyl-d-aspartate (NMDA) receptor activation. These data suggest that Ca2+ release from intracellular stores is required for the induction of LTP.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalNeuroscience Letters
Volume139
Issue number2
Early online date19 Mar 1992
DOIs
Publication statusPublished - 25 May 1992

Keywords

  • Ca
  • Ca pool
  • Hippocampus
  • LTP
  • NMDA receptor
  • Synaptic plasticity

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