The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

Daniel T. Baptista-Hon; Tarek Z. Deeb; Nidaa A. Othman; Douglas Sharp; Tim G. Hales

doi:10.1111/j.1476-5381.2011.01582.x

The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

Daniel T. Baptista-Hon, Tarek Z. Deeb, Nidaa A. Othman, Douglas Sharp, Tim G. Hales (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Morphine is an antagonist at 5-HT(3) A receptors. 5-HT(3) and opioid receptors are expressed in many of the same neuronal pathways where they modulate gut motility, pain and reinforcement. There is increasing interest in the 5-HT3B subunit, which confers altered pharmacology to 5-HT(3) receptors. We investigated the mechanisms of inhibition by morphine of 5-HT(3) receptors and the influence of the 5-HT3B subunit.

Original language	English
Pages (from-to)	693-704
Number of pages	12
Journal	British Journal of Pharmacology
Volume	165
Issue number	3
DOIs	https://doi.org/10.1111/j.1476-5381.2011.01582.x
Publication status	Published - 2012

Keywords

alkaloids
Cys-loop receptors
electrophysiology
drug dependence
opiates
SINGLE-CHANNEL CONDUCTANCE
GATED ION-CHANNEL
STRUCTURAL DETERMINANTS
MOLECULAR DETERMINANTS
NEUROBLASTOMA-CELLS
TYPE-3 RECEPTORS
PLACE-PREFERENCE
HEROIN-ADDICTION
5-HYDROXYTRYPTAMINE
BINDING

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10.1111/j.1476-5381.2011.01582.x

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abstract = "Morphine is an antagonist at 5-HT(3) A receptors. 5-HT(3) and opioid receptors are expressed in many of the same neuronal pathways where they modulate gut motility, pain and reinforcement. There is increasing interest in the 5-HT3B subunit, which confers altered pharmacology to 5-HT(3) receptors. We investigated the mechanisms of inhibition by morphine of 5-HT(3) receptors and the influence of the 5-HT3B subunit.",

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AU - Deeb, Tarek Z.

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AU - Sharp, Douglas

AU - Hales, Tim G.

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The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

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Keywords

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