The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

Daniel T. Baptista-Hon, Tarek Z. Deeb, Nidaa A. Othman, Douglas Sharp, Tim G. Hales (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Morphine is an antagonist at 5-HT(3) A receptors. 5-HT(3) and opioid receptors are expressed in many of the same neuronal pathways where they modulate gut motility, pain and reinforcement. There is increasing interest in the 5-HT3B subunit, which confers altered pharmacology to 5-HT(3) receptors. We investigated the mechanisms of inhibition by morphine of 5-HT(3) receptors and the influence of the 5-HT3B subunit.
    Original languageEnglish
    Pages (from-to)693-704
    Number of pages12
    JournalBritish Journal of Pharmacology
    Volume165
    Issue number3
    DOIs
    Publication statusPublished - 2012

    Keywords

    • alkaloids
    • Cys-loop receptors
    • electrophysiology
    • drug dependence
    • opiates
    • SINGLE-CHANNEL CONDUCTANCE
    • GATED ION-CHANNEL
    • STRUCTURAL DETERMINANTS
    • MOLECULAR DETERMINANTS
    • NEUROBLASTOMA-CELLS
    • TYPE-3 RECEPTORS
    • PLACE-PREFERENCE
    • HEROIN-ADDICTION
    • 5-HYDROXYTRYPTAMINE
    • BINDING

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