The adenomatous polyposis coli protein 30 years on

James Abbott; Inke Nathke

doi:10.1101/2022.11.14.516391

The adenomatous polyposis coli protein 30 years on

Computational Biology

Research output: Working paper/Preprint › Preprint

Abstract

Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space. APC is a multifunctional protein, with roles as a key scaffold protein in complexes involved in diverse signalling pathways, most prominently the Wnt signalling pathway. APC is also a cytoskeletal regulator with direct and indirect links to and impacts on all three major cytoskeletal networks. Here, we interrogate the enormous depth of sequencing data now available to reveal the conservation of APC across taxonomy and relationships between different APC protein families.

Original language	English
Publisher	BioRxiv
Pages	1-21
Number of pages	21
DOIs	https://doi.org/10.1101/2022.11.14.516391
Publication status	Published - 15 Nov 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1101/2022.11.14.516391Licence: CC BY-NC-ND

The adenomatous polyposis coli protein 30 years on
Abbott, J. & Nathke, I. S. (Lead / Corresponding author), Dec 2023, In: Seminars in Cell & Developmental Biology. 150-151, p. 28-34 7 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
14 Link opens in a new tab Citations (Scopus)

209 Downloads (Pure)

Cite this

@techreport{f53a38172f334a509e68165bea928d70,

title = "The adenomatous polyposis coli protein 30 years on",

abstract = "Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space. APC is a multifunctional protein, with roles as a key scaffold protein in complexes involved in diverse signalling pathways, most prominently the Wnt signalling pathway. APC is also a cytoskeletal regulator with direct and indirect links to and impacts on all three major cytoskeletal networks. Here, we interrogate the enormous depth of sequencing data now available to reveal the conservation of APC across taxonomy and relationships between different APC protein families.",

author = "James Abbott and Inke Nathke",

note = "Copyright: The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.",

year = "2022",

month = nov,

day = "15",

doi = "10.1101/2022.11.14.516391",

language = "English",

pages = "1--21",

publisher = "BioRxiv",

address = "United States",

type = "WorkingPaper",

institution = "BioRxiv",

}

TY - UNPB

T1 - The adenomatous polyposis coli protein 30 years on

AU - Abbott, James

AU - Nathke, Inke

N1 - Copyright: The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

PY - 2022/11/15

Y1 - 2022/11/15

N2 - Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space. APC is a multifunctional protein, with roles as a key scaffold protein in complexes involved in diverse signalling pathways, most prominently the Wnt signalling pathway. APC is also a cytoskeletal regulator with direct and indirect links to and impacts on all three major cytoskeletal networks. Here, we interrogate the enormous depth of sequencing data now available to reveal the conservation of APC across taxonomy and relationships between different APC protein families.

AB - Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space. APC is a multifunctional protein, with roles as a key scaffold protein in complexes involved in diverse signalling pathways, most prominently the Wnt signalling pathway. APC is also a cytoskeletal regulator with direct and indirect links to and impacts on all three major cytoskeletal networks. Here, we interrogate the enormous depth of sequencing data now available to reveal the conservation of APC across taxonomy and relationships between different APC protein families.

U2 - 10.1101/2022.11.14.516391

DO - 10.1101/2022.11.14.516391

M3 - Preprint

SP - 1

EP - 21

BT - The adenomatous polyposis coli protein 30 years on

PB - BioRxiv

ER -

The adenomatous polyposis coli protein 30 years on

Abstract

UN SDGs

Access to Document

Fingerprint

Research output

The adenomatous polyposis coli protein 30 years on

Cite this