TY - JOUR
T1 - The adenomatous polyposis coli protein
T2 - the Achilles heel of the gut epithelium
AU - Nathke, Inke S.
PY - 2004
Y1 - 2004
N2 - The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of ß-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.
AB - The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of ß-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.
U2 - 10.1146/annurev.cellbio.20.012103.094541
DO - 10.1146/annurev.cellbio.20.012103.094541
M3 - Article
C2 - 15473844
SN - 1081-0706
VL - 20
SP - 337
EP - 366
JO - Annual Review of Cell and Developmental Biology
JF - Annual Review of Cell and Developmental Biology
ER -
