The adjuvant benefit of angioplasty in patients with mild to moderate intermittent claudication (MIMIC) managed by supervised exercise, smoking cessation advice and best medical therapy: results from two randomised trials for stenotic femoropopliteal and aortoiliac arterial disease the MIMIC trial participants (See Appendix 1)

R. M. Greenhalgh, J. J. F. Belch, L. C. Brown, P. A. Gaines, L. Gao, J. A. Reise, S. G. Thompson, MIMIC Trial Participants

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    Abstract

    Background: Uncertainty exists on whether there is adjuvant benefit of percutaneous transluminal angioplasty (PTA) over supervised exercise and best medical therapy in the treatment of intermittent claudication.

    Methods: Patients with symptoms of stable mild to moderate intermittent claudication (MIMIC) were randomised in two multi-centre trials, for femoropopliteal and aortoiliac arterial disease, to receive either PTA or no PTA against a background of supervised exercise and best medical therapy and followed up for 24 months. Initial claudication distance (ICD) and absolute walking distance (AWD) on treadmill were compared between randomised groups adjusting for the corresponding measure at baseline. Secondary outcomes included ankle-brachial pressure index (ABPI) and quality of life.

    Findings: A total of 93 patients were randomised into the femoropopliteal trial (48 into PTA) and 34 into the aortoiliac trial (19 to PTA). The mean (standard deviation, SD) age was 66(9) years for the femoropopliteal trial (63% male) and 63(9) for the aortoiliac trial (65% mate). At 24 months, there were significant improvements in both AWD and ICD in the PTA groups for both trials. The adjusted AWD was 38% greater in the PTA group for the femoropopliteal trial (95%; CI 1-90) (p = 0.04) and 78% greater in the PTA group for the aortoiliac trial (95%; CI 0-216) (p = 0.05). Further benefits were demonstrated for ABPI but not for quality of life.

    Interpretation: PTA confers adjuvant benefit over supervised exercise and best medical therapy in terms of walking distances and ABPI 24 months after PTA in patients with stable mild to moderate intermittent claudication. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)680-688
    Number of pages9
    JournalEuropean Journal of Vascular and Endovascular Surgery
    Volume36
    Issue number6
    DOIs
    Publication statusPublished - 2008

    Keywords

    • Percutaenous transluminal angioplasty
    • Intermittent claudication
    • Femoropopliteal
    • Aortoiliac
    • Occlusive or stenotic arterial disease
    • Walking distance
    • Treadmill test
    • ABPI
    • PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY
    • SUPERFICIAL FEMORAL-ARTERY
    • NITINOL STENT IMPLANTATION
    • WALKING DISTANCE
    • LESIONS

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