The airway microbiome in asthma

TY - JOUR

T1 - The airway microbiome in asthma

AU - Richardson, Hollian

AU - Headley, Daniela Alferes de Lima

AU - Hull, Rebecca C.

AU - Chalmers, James D.

N1 - Publisher Copyright: © ERS 2025.

PY - 2025/6/1

Y1 - 2025/6/1

N2 - The microbiome, especially in early life, may play a role in asthma development and its severity. Early microbial interactions with the immune system are crucial for health, with exposure to bacteria like Streptococcus, Haemophilus and Moraxella linked to asthma in later childhood. C-sections, antibiotics and formula feeding affect microbiome development, increasing asthma risk. In adults with asthma, bacteria like Haemophilus influenzae and Moraxella catarrhalis are more prevalent. Commensal bacteria, such as Rothia mucilaginosa, can influence inflammation through mechanisms like NF-κB signalling. The lung–gut axis also plays a role in asthma development, with short-chain fatty acids from the gut potentially modulating immune responses. Emerging research suggests dietary interventions could aid asthma management. Multi-omics is being used to identify asthma endotypes, which may lead to precision medicines and new treatments. However, further research is needed to validate these findings and better understand asthma mechanisms.

AB - The microbiome, especially in early life, may play a role in asthma development and its severity. Early microbial interactions with the immune system are crucial for health, with exposure to bacteria like Streptococcus, Haemophilus and Moraxella linked to asthma in later childhood. C-sections, antibiotics and formula feeding affect microbiome development, increasing asthma risk. In adults with asthma, bacteria like Haemophilus influenzae and Moraxella catarrhalis are more prevalent. Commensal bacteria, such as Rothia mucilaginosa, can influence inflammation through mechanisms like NF-κB signalling. The lung–gut axis also plays a role in asthma development, with short-chain fatty acids from the gut potentially modulating immune responses. Emerging research suggests dietary interventions could aid asthma management. Multi-omics is being used to identify asthma endotypes, which may lead to precision medicines and new treatments. However, further research is needed to validate these findings and better understand asthma mechanisms.

UR - https://www.scopus.com/pages/publications/105011094942

U2 - 10.1183/2312508X.10013724

DO - 10.1183/2312508X.10013724

M3 - Article

AN - SCOPUS:105011094942

SN - 2312-508X

VL - 2025

SP - 85

EP - 101

JO - ERS Monograph

JF - ERS Monograph

IS - 108

ER -