The amino acid sequence of a mammalian MAP kinase kinase

A. Ashworth, S. Nakielny, P. Cohen, C. Marshall

    Research output: Contribution to journalArticlepeer-review

    62 Citations (Scopus)


    The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing. MAPKK (393 residues, Mr 43,330) is a new member of the protein kinase subclass that comprises byr1 and STE7 that are involved in pheromone dependent signal transduction in yeast, wis1 a mitotic regulator in S. pombe and PBS2, which confers antibiotic resistance in S. cerevisiae.

    Original languageEnglish
    Pages (from-to)2555-2556
    Number of pages2
    Issue number12
    Publication statusPublished - 1992

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics
    • Cancer Research


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