The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

Jackie M Kinsella, Hilary A Laidlaw, Teresa Tang, Jenni Harvey, Calum Sutherland, Michael L J Ashford

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    3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.

    Original languageEnglish
    Number of pages13
    JournalBMC Clinical Pharmacology
    Issue number17
    Publication statusPublished - 2004


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