The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

Jackie M Kinsella, Hilary A Laidlaw, Teresa Tang, Jenni Harvey, Calum Sutherland, Michael L J Ashford

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.

    Original languageEnglish
    Number of pages13
    JournalBMC Clinical Pharmacology
    Volume4
    Issue number17
    DOIs
    Publication statusPublished - 2004

    Fingerprint

    Obese Mice
    KATP Channels
    Insulinoma
    Leptin
    Adenosine Triphosphate
    Body Weight
    Cell Line
    BVT.12777
    pimagedine
    guanidinopropionic acid

    Cite this

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    title = "The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1",
    abstract = "3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.",
    author = "Kinsella, {Jackie M} and Laidlaw, {Hilary A} and Teresa Tang and Jenni Harvey and Calum Sutherland and Ashford, {Michael L J}",
    year = "2004",
    doi = "10.1186/1471-2210-4-17",
    language = "English",
    volume = "4",
    journal = "BMC Clinical Pharmacology",
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    publisher = "Springer Verlag",
    number = "17",

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    The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1. / Kinsella, Jackie M; Laidlaw, Hilary A; Tang, Teresa; Harvey, Jenni; Sutherland, Calum; Ashford, Michael L J.

    In: BMC Clinical Pharmacology, Vol. 4, No. 17, 2004.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

    AU - Kinsella, Jackie M

    AU - Laidlaw, Hilary A

    AU - Tang, Teresa

    AU - Harvey, Jenni

    AU - Sutherland, Calum

    AU - Ashford, Michael L J

    PY - 2004

    Y1 - 2004

    N2 - 3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.

    AB - 3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.

    U2 - 10.1186/1471-2210-4-17

    DO - 10.1186/1471-2210-4-17

    M3 - Article

    VL - 4

    JO - BMC Clinical Pharmacology

    JF - BMC Clinical Pharmacology

    SN - 1472-6904

    IS - 17

    ER -