The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

Jackie M Kinsella; Hilary A Laidlaw; Teresa Tang; Jenni Harvey; Calum Sutherland; Michael L J Ashford

doi:10.1186/1471-2210-4-17

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K⁺ channels in the rat insulinoma cell line, CRI-G1

Jackie M Kinsella
, Hilary A Laidlaw
, Teresa Tang
, Jenni Harvey
, Calum Sutherland
, Michael L J Ashford

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens K_ATP channels in rat insulinoma cells, by the same mechanism as leptin.

Original language	English
Number of pages	13
Journal	BMC Clinical Pharmacology
Volume	4
Issue number	17
DOIs	https://doi.org/10.1186/1471-2210-4-17
Publication status	Published - 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1186/1471-2210-4-17

Cite this

@article{07bebe92c31b4e6db7cda4144bb8c0f2,

title = "The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1",

abstract = "3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.",

author = "Kinsella, \{Jackie M\} and Laidlaw, \{Hilary A\} and Teresa Tang and Jenni Harvey and Calum Sutherland and Ashford, \{Michael L J\}",

year = "2004",

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language = "English",

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journal = "BMC Clinical Pharmacology",

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T1 - The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

AU - Kinsella, Jackie M

AU - Laidlaw, Hilary A

AU - Tang, Teresa

AU - Harvey, Jenni

AU - Sutherland, Calum

AU - Ashford, Michael L J

PY - 2004

Y1 - 2004

N2 - 3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.

AB - 3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinoma cells, by the same mechanism as leptin.

U2 - 10.1186/1471-2210-4-17

DO - 10.1186/1471-2210-4-17

M3 - Article

C2 - 15329154

VL - 4

JO - BMC Clinical Pharmacology

JF - BMC Clinical Pharmacology

IS - 17