Projects per year
Abstract
Mutations in PINK1, which impair its catalytic kinase activity, are causal for autosomal recessive early-onset Parkinson's disease (PD). Various studies have indicated that the activation of PINK1 could be a useful strategy in treating neurodegenerative diseases, such as PD. Herein, it is shown that the anthelmintic drug niclosamide and its analogues are capable of activating PINK1 in cells through the reversible impairment of the mitochondrial membrane potential. With these compounds, for the first time, it is demonstrated that the PINK1 pathway is active and detectable in primary neurons. These findings suggest that niclosamide and its analogues are robust compounds for the study of the PINK1 pathway and may hold promise as a therapeutic strategy in PD and related disorders.
Original language | English |
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Pages (from-to) | 425-429 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 19 |
Issue number | 5 |
Early online date | 10 Dec 2017 |
DOIs | |
Publication status | Published - 2 Mar 2018 |
Keywords
- Drug discovery
- Membranes
- Mitochondria
- Neurodegenerative diseases
- Proteins
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry
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Dive into the research topics of 'The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1'. Together they form a unique fingerprint.Projects
- 4 Finished
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Structural Analysis of the Parkinson's Associated Kinase PINK1
Muqit, M. (Investigator) & van Aalten, D. (Investigator)
1/11/15 → 31/10/16
Project: Research
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Investigation of the Regulation of Rab GTPases by PINK1 (PhD Studentship)
Muqit, M. (Investigator)
7/09/15 → 6/09/18
Project: Research
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Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)
Muqit, M. (Investigator)
1/07/13 → 31/12/23
Project: Research
Student theses
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
Mulholland, K. E. (Author), Muqit, M. (Supervisor) & Alessi, D. (Supervisor), 2019Student thesis: Doctoral Thesis › Doctor of Philosophy
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