Abstract
Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.
Original language | English |
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Pages (from-to) | 247-253 |
Number of pages | 7 |
Journal | Seminars in Immunology |
Volume | 2 |
Issue number | 4 |
Publication status | Published - Jul 1990 |
Keywords
- Antigen processing
- B lymphocyte
- Endocytosis
- Epitope
- Immunoglobulin
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology