The antigen processing pathway in B lymphocytes

Colin Watts, Pamela A. Reid, Michele A. West, Howard W. Davidson

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.

    Original languageEnglish
    Pages (from-to)247-253
    Number of pages7
    JournalSeminars in Immunology
    Issue number4
    Publication statusPublished - Jul 1990


    • Antigen processing
    • B lymphocyte
    • Endocytosis
    • Epitope
    • Immunoglobulin

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology


    Dive into the research topics of 'The antigen processing pathway in B lymphocytes'. Together they form a unique fingerprint.

    Cite this