The antigen processing pathway in B lymphocytes

Colin Watts, Pamela A. Reid, Michele A. West, Howard W. Davidson

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalSeminars in Immunology
Volume2
Issue number4
Publication statusPublished - Jul 1990

Keywords

  • Antigen processing
  • B lymphocyte
  • Endocytosis
  • Epitope
  • Immunoglobulin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'The antigen processing pathway in B lymphocytes'. Together they form a unique fingerprint.

Cite this